The Journal of Practical Medicine ›› 2025, Vol. 41 ›› Issue (20): 3228-3234.doi: 10.3969/j.issn.1006-5725.2025.20.012
• Clinical Research • Previous Articles
Yanmin ZHENG1,Qingqing WANG2,Shenghao LI2(
),Ye LI1,Lu. ZHANG1
Received:2025-07-16
Online:2025-10-25
Published:2025-11-05
Contact:
Shenghao LI
E-mail:doctorlee3h@163.com
CLC Number:
Yanmin ZHENG,Qingqing WANG,Shenghao LI,Ye LI,Lu. ZHANG. Analysis of factors influencing hyperdynamic circulation indicators in patients with liver cirrhosis and ascites[J]. The Journal of Practical Medicine, 2025, 41(20): 3228-3234.
Tab.1
Distribution characteristics and intergroup comparisons of sociodemographic, clinical, and echocardiographic data"
| 变量 | 1级腹水组(n = 107) | 2级腹水组(n = 237) | 3级腹水组(n = 33) | Z/χ2 值 | P值 |
|---|---|---|---|---|---|
| 年龄/岁 | 54.00(47.00,60.00) | 56.00(48.00,64.50) | 58.00(50.50,64.00) | 3.959 | 0.138 |
| 性别/[例(%)] | 3.239 | 0.198 | |||
| 男 | 70(65.42) | 166(70.04) | 27(81.81) | ||
| 女 | 37(34.57) | 71(29.95) | 6(18.18) | ||
| 病因/[例(%)] | 8.716 | 0.190 | |||
| 病毒性 | 83(77.57) | 167(70.46) | 19(57.57) | ||
| 酒精性 | 7(6.54) | 29(12.24) | 7(21.21) | ||
| 病毒性+酒精性 | 6(5.60) | 20(8.44) | 2(6.06) | ||
| 其他 | 11(10.28) | 21(8.86) | 5(15.15) | ||
| 消化道出血症状/[例(%)] | 6.067 | 0.048 | |||
| 有 | 5(4.67) | 25(10.54) | 6(18.18) | ||
| 无 | 102(95.33) | 212(89.46) | 27(81.82) | ||
| HR/BPM | 80.00(72.00,88.00) | 84.00(74.00,94.00) | 90.00(84.00,98.00) | 14.361 | 0.001 |
| EF/% | 68.00(63.00,72.00) | 68.00(64.00,73.00) | 69.00(65.00,72.00) | 1.736 | 0.420 |
| FS/% | 38.00(34.00,41.00) | 38.00(34.20,42.50) | 39.00(36.00,42.00) | 2.642 | 0.267 |
| SV/mL | 71.00(63.00,80.00) | 71.00(61.00,81.50) | 74.00(57.00,88.50) | 0.547 | 0.761 |
| LVDF/[例(%)] | 7.502 | 0.023 | |||
| 异常组 | 43(40.29) | 126(53.27) | 21(63.64) | ||
| 正常组 | 64(59.81) | 111(46.83) | 12(36.36) | ||
| E/A/(cm/s) | 1.20(0.70,1.30) | 0.90(0.70,1.30) | 0.80(0.70,1.00) | 15.040 | 0.001 |
| RDW-CV/% | 15.00(13.60,17.20) | 15.70(14.40,17.20) | 15.10(14.30,17.15) | 5.427 | 0.066 |
| ALB | 32.00(27.60,36.10) | 28.30(24.70,31.40) | 25.00(22.65,27.15) | 45.468 | < 0.001 |
| K+/(mmol/L) | 3.88(3.66,4.10) | 3.75(3.43,4.95) | 3.92(3.50,4.19) | 6.558 | 0.038 |
| Cl-/(mmol/L) | 107.80(105.00,109.90) | 106.40(102.95,109.60) | 104.10(99.85,107.90) | 8.133 | 0.017 |
| TBIL/(μmol/L) | 26.80(17.40,57.50) | 34.30(18.75,74.30) | 36.2((15.10,58.55) | 1.683 | 0.431 |
| DBIL/(μmol/L) | 11.40(6.90,30.60) | 16.30(7.50,47.95) | 18.70(7.95,25.95) | 3.039 | 0.219 |
| Urea/(mmol/L) | 4.86(3.86,6.30) | 5.35(3.92,7.50) | 7.00(5.04,9.73) | 11.873 | 0.003 |
| Crea/(mmol/L) | 60.00(52.00,74.00) | 64.00(51.00,80.00) | 75.00(62.50,91.50) | 12.882 | 0.002 |
| AFP/(U/L) | 6.10(2.93,19.01) | 5.64(2.85,77.73) | 3.82(1.98,14.59) | 3.021 | 0.221 |
Tab.2
Correlations of heart rate and e/a ratio with basic clinical parameters in patients with cirrhosis and ascites"
| 变量 | HR | E/A | 变量 | HR | E/A | ||||
|---|---|---|---|---|---|---|---|---|---|
| r值 | P值 | r值 | P值 | r值 | P值 | r值 | P值 | ||
| 年龄 | -0.156 | 0.002 | -0.307 | < 0.001 | PA/(g/L) | -0.212 | < 0.001 | 0.005 | 0.923 |
| 性别 | -0.700 | 0.484 | -0.979 | 0.328 | ALB/(g/L) | -0.154 | 0.003 | 0.220 | < 0.001 |
| 病因 | 3.084 | 0.027 | 8.935 | 0.030 | GLOB/(g/L) | 0.022 | 0.665 | -0.119 | 0.021 |
| WBC/(×109/L-1) | 0.196 | < 0.001 | -0.207 | < 0.001 | CHE/(U/L) | -0.149 | 0.004 | 0.054 | 0.301 |
| LYMP/(×109/L-1) | -0.005 | 0.917 | -0.082 | 0.112 | TG/(mmol/L) | 0.079 | 0.128 | -0.098 | 0.065 |
| NEUT/(×109/L-1) | 0.216 | < 0.001 | -0.210 | < 0.001 | CHOL/(mmol/L) | -0.159 | 0.002 | -0.053 | 0.321 |
| UA/(mol/L) | -0.021 | 0.687 | -0.143 | 0.006 | HDL-C/(mmol/L) | -0.217 | < 0.001 | 0.004 | 0.934 |
| GLU/(mmol/L) | 0.181 | < 0.001 | -0.128 | 0.013 | LDL-C/(mmol/L) | -0.096 | 0.062 | -0.127 | 0.016 |
| HCT/% | -0.139 | 0.007 | 0.063 | 0.228 | CEA/(g/L) | 0.037 | 0.474 | -0.159 | 0.002 |
| PLT/(×109/L-1) | 0.046 | 0.372 | -0.198 | < 0.001 | AFP/(U/L) | 0.045 | 0.381 | 0.074 | 0.150 |
| RDW-CV/% | 0.138 | 0.007 | 0.083 | 0.109 | CA125/(U/mL) | 0.267 | < 0.001 | -0.250 | < 0.001 |
| K+/(mmol/L) | -0.052 | 0.310 | -0.056 | 0.277 | CA199/(U/mL) | 0.098 | 0.057 | -0.116 | 0.026 |
| Na+/(mmol/L) | -0.266 | < 0.001 | 0.101 | 0.051 | PT/s | 0.128 | 0.013 | 0.081 | 0.120 |
| Cl-(mmol/L) | -0.258 | < 0.001 | 0.095 | 0.065 | PTA/% | -0.145 | 0.005 | -0.060 | 0.246 |
| CO2/(mmol/L) | -0.130 | 0.011 | 0.068 | 0.189 | INR | 0.125 | 0.015 | 0.067 | 0.197 |
| UREA/(mmol/L) | 0.040 | 0.437 | -0.116 | 0.024 | 腹水量/mL | 0.200 | < 0.001 | -0.187 | < 0.001 |
| TBIL/(mol/L) | 0.132 | 0.011 | 0.047 | 0.359 | CTP | 0.207 | < 0.001 | -0.130 | 0.012 |
| DBIL/(mol/L) | 0.148 | 0.004 | 0.035 | 0.498 | MELD | 0.125 | 0.015 | 0.054 | 0.297 |
Tab.3
Comparison of basic clinical characteristics between patients with and without left ventricular diastolic dysfunction"
| 变量 | 正常组(n = 187) | 异常组(n = 190) | Z/χ2 /t值 | P值 |
|---|---|---|---|---|
| 年龄/岁 | 52.00(44.00,58.00) | 59.00(53.00,67.00) | -7.472 | < 0.001 |
| 性别/[例(%)] | 6.706 | 0.010 | ||
| 男 | 121(63.70) | 142(75.90) | ||
| 女 | 69(36.30) | 45(24.10) | ||
| 肝硬化病因/ | 8.210 | 0.042 | ||
| 病毒性 | 124(65.30) | 145(77.50) | ||
| 酒精性 | 26(13.70) | 17(9.10) | ||
| 病毒+酒精性 | 15(7.90) | 13(7.00) | ||
| 其他 | 25(13.20) | 12(3.20) | ||
| 腹水量/mm | 52.50(26.00,79.00) | 42.00(20.50,74.00) | -1.963 | 0.050 |
| WBC/(×109/L-1) | 4.20(2.86,6.99) | 4.98(3.51,7.15) | -2.384 | 0.017 |
| LYMP/(×109/L-1) | 0.87(0.55,1.20) | 0.96(0.64,1.27) | -1.804 | 0.071 |
| NEUT/(×109/L-1) | 2.76(1.77,4.98) | 3.29(2.17,5.05) | -2.233 | 0.026 |
| PLT/(×109/L-1) | 84.00(52.00,125.00) | 101.00(70.00,143.00) | -2.749 | 0.006 |
| RDW-CV( | 16.35 ± 2.82 | 15.78 ± 2.45 | 2.001 | 0.046 |
| K+( | 3.75 ± 0.51 | 3.85 ± 0.55 | -1.949 | 0.052 |
| Na+/(mmol/L) | 138.40(135.68,140.93) | 138.40(135.75,140.55) | -0.589 | 0.556 |
| Ca2+/(mmol/L) | 2.09(1.95,2.19) | 2.04(1.93,2.20) | -0.673 | 0.501 |
| Cl-/(mmol/L) | 106.80(103.78,109.65) | 106.50(102.90,109.70) | -0.39 | 0.697 |
| UA/(mmol/L) | 292.00(235.50,374.50) | 326.00(247.50,430.00) | -1.954 | 0.051 |
| ALB/(U/L) | 30.10(25.95,33.88) | 27.40(24.55,31.10) | -3.780 | < 0.001 |
| GLOB/(U/L) | 29.70(26.10,35.63) | 32.20(27.55,37.65) | -2.551 | 0.011 |
| CHE/(mmol/L) | 2883.00(2035.50,3999.75) | 2821.00(2074.00,4006.00) | -0.124 | 0.901 |
| TG/(mmol/L) | 0.84(0.59,1.25) | 0.92(0.67,1.42) | -1.885 | 0.059 |
| CHOL/(mmol/L) | 3.07(2.41,3.86) | 3.48(2.71,4.44) | -3.125 | 0.002 |
| HDL-C/(mmol/L) | 0.75(0.32,1.07) | 0.75(0.40,1.06) | -0.500 | 0.617 |
| LDL-C/(mmol/L) | 1.69(1.30,2.25) | 2.01(1.44,2.75) | -3.179 | 0.001 |
| CEA/(U/L) | 3.14(1.97,4.77) | 3.68(2.44,5.13) | -2.677 | 0.007 |
| AFP/(U/L) | 5.51(2.92,35.26) | 5.81(2.70,63.21) | -0.125 | 0.901 |
| CA125/(U/L) | 105.25(32.90,273.98) | 218.70(71.60,518.32) | -4.332 | < 0.001 |
| INR | 1.43(1.26,1.60) | 1.37(1.26,1.57) | -1.146 | 0.252 |
| Child-Pugh总分 | 11.00(10.00,12.00) | 11.00(9.00,12.00) | -2.474 | 0.013 |
| MELD评分 | 13.32(10.24,16.71) | 12.78(9.56,16.66) | -0.527 | 0.598 |
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