miRNA在肠黏膜屏障功能中的作用研究进展

doi:10.3969/j.issn.1006-5725.2025.07.022

Abstract

Abstract:

The intestinal mucosal barrier plays a pivotal role in both innate and adaptive immune regulation. Its integrity is essential for maintaining overall health， as it acts as a critical interface between the luminal contents and the host immune system. MicroRNAs （miRNAs）， which are small noncoding RNAs， function as potent genetic regulators by interacting with multiple target genes to modulate entire cellular pathways. Recent studies have demonstrated that miRNAs are intricately involved in regulating the function of the intestinal mucosal barrier. This review examines the role of miRNAs in the intestinal mucosal barrier， encompassing their mechanisms， relevant clinical research findings， and potential directions for future investigation， to elucidate the potential value of miRNAs in the pathogenesis， diagnosis， and treatment of related diseases.

Key words: miRNA, intestinal mucosal barrier, IECs

CLC Number:

R574

Bangrong XU,Zhenghua JIANG,Xin CHEN,Jun CHEN,Haibo LUO,Daoming LIANG. The role and research progress of miRNA in intestinal mucosal barrier function[J]. The Journal of Practical Medicine, 2025, 41(7): 1079-1083.

Figures/Tables 1

Tab.1

References 47

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miRNA类型	作用方式	作用结果	疾病类型	作用靶点	信号通路	参考文献
miR-429	下调	↑	结肠炎	/	AhR-miR-429	［25］
miR-218a-5p	上调	↑	急性胰腺炎	/	Notch1 and RhoA/ROCK	［26］
miR-155	下调	↑	酒精性肝炎	/	miRNA-155/SOCS 1/NF-κB	［27］
miR-211-5p	下调	↑	功能性消化不良	/	NEAT1/miR-211-5p/GDNF	［28］
miR-34a	下调	↑	动脉粥样硬化患者肠黏膜屏障功能	/	miR-34a/KLF4/NF-κB/tight unction protein	［29］
miR-221/222	下调	↑	反射性肠炎	/	P65-miR-221/222-Sdc1	［30］
miR-99a	上调	↑	重症急性胰腺炎	NOX4	/	［31］
miR-145-5p	上调	↑	克罗恩病	SOX9/CLDN8	miR-145-5p/SOX 9/CLDN 8	［32］
miR-495	上调	↑	溃疡性结肠炎	STAT3	JAK/STAT3	［33］
miR-155	下调	↑	大肠癌	/	TLR 4/NF-κB	［34］
miR-200	上调	↓	非酒精性脂肪肝/肠黏膜屏障功能障碍	SIRT1	microRNA-200 and the MAPK	［42］
miR-103a-3p	上调	↑	结肠炎	BRD4	Wnt/β-catenin	［35］
miR-181c	下调	↓	肠黏膜屏障	TNF-α	microRNA-181c/TNF-α/tight junction protein	［43］
miR-320	上调	↑	结肠炎相关性结直肠癌	IL-6R	IL-6R/STAT3	［36］
miR-155	下调	↓	脑损伤后的肠黏膜屏障功能	claudin 1	/	［44］
miR-320	上调	↑	烧伤后肠黏膜屏障功能	PTEN	Akt/Bad/Caspase	［37］
miR-31-5p	下调	↑	结肠炎	/	AMPK/SIRT 1/NLRP 3	［38］
miR-146b-5p	下调	↑	克罗恩病	/	MALAT1-miR146b-5p-CLDN11/NUMB	［39］
miR-124-3p	上调	↓	老年性结肠炎	T-synthase	miR-124-3p/T-synthase/O-glycans	［45］
miR-126	下调	↓	炎症性肠病	S1PR 2	PI3K/AKT	［46］
miR-182-5p	下调	↑	溃疡性结肠炎	claudin-2	/	［40］
miR-3061	下调	↓	糖尿病所致脓毒症肠损伤	Snail 1	/	［47］
miR-29a	下调	↑	腹泻型肠易激综合征	/	/	［41］

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The role and research progress of miRNA in intestinal mucosal barrier function

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