The Journal of Practical Medicine ›› 2023, Vol. 39 ›› Issue (22): 2989-2993.doi: 10.3969/j.issn.1006-5725.2023.22.023

• Investigations • Previous Articles     Next Articles

The molecular characteristics of ParechovirusA in patients with acute gastroenteritis in Sanya during 2019-2020

Liju HUANG1,Yongzhi LI2,Huan HE3,Tingli SHI1,Caiyun CHEN3,Liting ZHENG3,Minyi LIANG3,Jiaqi CHEN3,Qing. CHEN3()   

  1. *.Sanya Center for Disease Control and Prevention,Sanya 572002,China
  • Received:2023-09-19 Online:2023-11-25 Published:2023-12-11
  • Contact: Qing. CHEN E-mail:qch.2009@163.com

Abstract:

Objective To invesigate the prevalence and genetic characteristics of ParechovirusA (PeV-A) in tropical areas. Methods Acute diarrhea disease surveillance was conducted at Sanya Central Hospital between January 2019 and August 2020. Patient data and fecal specimens were collected. PeV-A was detected by nested RT-PCR, and phylogenetic analyses of specific gene sequences were performed. Results Two hundred and sixty-seven patients with acute gastroenteritis were included in this study. The PeV-A detection rate was 3.37% (9/267), and three PeV-A genotypes (HPeV1, HPeV3, and HPeV5) were detectable, which were most closely related to the reference strains from either Beijing or Hong Kong. The HPeV-positive patients were predominantly young children under the age of 2 years. The detection rate of PeV-A was higher in summer and winter (May to August and December to February, respectively). Patients with PeV-A-positive diarrhea had a higher proportion of respiratory infections, abdominal pain, vomiting, and fever than those with PeV-A-negative diarrhea. Rotavirus and norovirus were the most common viruses co-infected with PeV-A in patients with acute gastroenteritis. Conclusions PeV-A is an important pathogen of acute gastroenteritis in Sanya, and its prevalent genotypes are similar to those reported in other regions of China.

Key words: parechovirus A, acute gastroenteritis, epidemiology

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