The Journal of Practical Medicine ›› 2023, Vol. 39 ›› Issue (19): 2551-2555.doi: 10.3969/j.issn.1006-5725.2023.19.024

• Reviews • Previous Articles     Next Articles

Progress of SphK1/S1P in the biological behavior of tumor malignancy

Wenlu ZHANG1,Chunyan. XU2()   

  1. *.Department of Respiratory and Critical Care Medicine,Binzhou Medical University Hospital,Binzhou 256603,China
  • Received:2023-06-15 Online:2023-10-10 Published:2023-11-22
  • Contact: Chunyan. XU E-mail:xxswallow@163.com

Abstract:

Sphingophosphokinase 1 (SphK1) is a regulator of sphingomolipin metabolites that catalyzes the conversion of sphingosine-1-phosphate (S1P) to sphingosine-1-phosphate. SphK1/S1P is overexpressed in a variety of cancers. This paper reviewed the role and mechanism of SphK1/S1P in malignant biological behaviors of tumors, such as tumor cell proliferation, epithelial mesenchymal transformation, acquisition of stem-like properties, remodeling of tumor microenvironment, regulation of tumor immune function, and promotion of distant metastasis of tumor cells. It is suggested that SphK1/S1P plays a key role in multiple malignant biological behaviors of tumors.

Key words: sphingosin kinase 1, sphingosine-1-phosphate, malignant biological behavior of tumor

CLC Number: