Abstract:

Objective To investigate the effect of Hp on gastric juice microbiota in patients with gastric polyps. Methods Patients undergoing gastroscopy and Hp were selected. Patients with no abnormality of gastric mucosa and negative Hp under gastroscopy were assigned to healthy group，and patients with gastric polyps were assigned to case group. Gastric polyps were divided into polyp Hp（+）group and polyp Hp（-）group. Gastric juice was taken for 16SrRNA Gene Sequencing and bioinformatics analysis to compare the differences of microbiota and functional genes among different groups. Results There were no significant difference in α diversity and signifi⁃ cant differences in β diversity among the three groups（P < 0.05）. At the genus level，the abundance of Lachnoan⁃ aerobaculum and Oribacterium in polyp Hp（+）group was higher than that in polyp Hp（-）group. The abundance of aerobic bacteria in polyp Hp（-）group was significantly higher than that in the polyp Hp（+）group（P < 0.05）. There were differences among the three groups of microbiota in network topology parameters such as average clustering coefficient. Conclusion Hp infection disturbed the gastric microecological balance and made the gastric microbiota of gastric polyps disordered，which may affect the interaction between bacteria and bacteria and the role of bacteria host.

Key words:

gastric juice, gastric polyps, gastric microbiota, Helicobacter pylori