Abstract:

Objective To provide support for the diagnosis and treatment of COVID⁃19 patientscomplicated with bacterial infectionin our hospital by retrospectively analyze inflammatory indicators，distribution ofinfection strains and antibiotic susceptibility test. Methods The data on 125 patients with COVID⁃19 who had been treated and received bacterial and fungal cultures in our hospital from January 23，2020 to April 22，2020. PCT，WBC，and CRP，positive strains and antimicrobial susceptibility results were analyzed in combination with the clinical treat⁃ ment. Results Of 125 patients，19 were positive for bacterial or fungal culture；bacterial infection occurred in 12 （63.2%）patients and candida infection occurred in 7（36.8%）patients. There were significant differences in mean age，presence of underlying diseases，and clinical typing of COVID⁃19 pneumonia between culture⁃positive and ⁃neg⁃ ative groups（P < 0.01）；The inflammatory indicators PCT，WBC and CRP were increased at different levels in cul⁃ ture⁃positive patients，and differed significantly between culture⁃negative and ⁃positive patients（P < 0.01）. Moxi⁃ floxacin and cefoperazone ⁃ sulbactam showed significant efficacy in the treatment of bacterial or fungal infection. Conclusions COVID⁃19 patients are at risk for nosocomial bacterial or fungal infection，and develop sepsis，re⁃ spiratory and genitourinary infections. WBC，PCT and CRP can be used as the differential indicators of bacterial or fungal infection in COVID⁃19 pneumonia patients. Timely bacterial or fungal culture and antibiotic susceptibility test 

Key words: