Abstract:

Osteonecrosis of the femoral head is one of the common diseases in orthopedics. It is a progres⁃ sive disease. If it is not intervened in time in the early stage，it will lead to progressive destruction of the femoral head，and eventually result in the collapse of the structure of the femoral head，which is seriously affecting the quality of life. At present，the clinical treatment of osteonecrosis of the femoral head is mainly based on the ARCO stage and the condition of the patients. Hip arthroplasty is often used for advanced patients，but due to the limited life span of the prosthesis and the younger trend of the patient′s age，the effect of this treatment is not satisfactory. For early patients，a series of conservative treatment and hip preservation can be used，such as drug intervention， lifestyle improvement，core decompression，autogenous bone transplantation and so on，but the clinical effect is not satisfactory. With the continuous maturity of tissue engineering and regenerative medicine and the good character⁃ istics of bone marrow mesenchymal stem cells ，BMSCs has become a hot seed cell in clinical basic research. Researchers have observed a certain effect of BMSCs combined with other treatments in the treatment of osteonecro⁃ sis of the femoral head. With the continuous development of related research，the application of BMSCs in the treat⁃ ment of ONFHis expected to become a satisfactory treatment in the future.

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