关键词:

高流量氧疗湿化治疗仪, 还原型谷胱甘肽, 慢性阻塞性肺疾病急性加重期, 疗效, 炎症因子, 氧化应激反应

Abstract:

Objective To explore the curative effect of high flow humidified oxygen delivery device combined with glutathione（GSH）on patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）and its influences on levels of serum inflammatory factors. Methods A total of 128 patients with AECOPD admitted to the hospital from April 2021 to May 2022 were enrolled as the research objects. They were randomly divided into control group treated with high flow humidified oxygen delivery device and observation group treated with high flow humidified oxygen delivery device and GSH，with 64 cases in each group. Bothgroups were continuously treated for 2 weeks. The clinical curative effect in both groups was evaluated. Before and after treat⁃ ment，changes in levels of serum inflammatory factors［serum cystatin C（CysC），C⁃reactive protein（CRP），pro⁃ calcitonin（PCT），matrix metalloproteinase（MMP）⁃9］，oxidative stress indexes［superoxide dismutase（SOD）， glutathione peroxidase（GSH ⁃ PX），malondialdehyde（MDA），catalase（CAT）］，pulmonary function indexes ［peak expiratory flow（PEF），forced expiratory volume in 1s（FEV1），FEV1/forced vital capacity（FVC）］and blood gas indexes［pH，partial pressure of carbon dioxide（PaCO2），arterial partial pressure of oxygen（PaO2）］ were compared. The incidence of adverse events was recorded. Results The total clinical response rate in the observation group was significantly higher than that in the control group（96.88% vs. 87.50%，P < 0.05）. Levels ofPCT，CysC，CRP and MMP ⁃ 9 in both groups were decreased，which were especially lower in the observation group（P < 0.05）. Levels of SOD，GSH⁃PX，CAT，PEF，FEV1 and FEV1/FVC in the observation group were higher than those in the control group，while MDA was lower than that in the control group（P < 0.05）. pH and PaO2 in the observation group were higher than those in the control group，while PaCO2 was lower than that in control group （P < 0.05）. There was no significant difference in the incidence of adverse events between the two groups（3.12% vs. 4.69%，P > 0.05）. Conclusion Curative effect of high flow humidified oxygen delivery device combined with GSH is good for AECOPD patients，which is conducive to relieving inflammation and stress response，improving pulmonary function and arterial blood gas.

Key words:

"> high flow humidified oxygen delivery device, glutathione, acute exacerbation of chronic obstructive pulmonary disease, curative effect, inflammatory factor, oxidative stress response