关键词: 新型冠状病毒肺炎, 心肌损伤, 炎症

Abstract:

Objective To explore the correlation between myocardial injury and inflammation in patientswith new coronavirus pneumonia（COVID⁃19）. Methods A retrospective study was conducted in 120 COVID⁃19patients who admitted to Wuhan First Hospital from January 20，2020 to March 20，2020. According to the clinicalclassification of COVID⁃19，these patients were divided into mild group（common type）and severe group（severeand critical type）. The clinical characteristics and Laboratory test，such as high⁃sensitivity troponin I（hs⁃TNI），creatine kinase⁃MB isoenzyme（CK⁃MB），lactate dehydrogenase（LDH），C⁃reactive protein（CRP），procalcitonin（PCT），white blood cell（WBC），neutrophil Cell（NEUT）and lymphocyte（LYM），were analyzed and comparedbetween the two groups. Furthermore，the difference and correlation were analyzed and compared. Results Firstly，among the three clinical types，the differences were statistically significant in age，gender，hypertension，coronaryheart disease and arrhythmia（all P < 0.05）. Secondly，the expressionof CK⁃MB，LDH and CRP and the proportionsof those abnormal indicators in the severe group were significantly increased，the same with the WBC and NEU，but opposite to the LYM（all P < 0.05）. Further more，in the severe group，the expressionof hs⁃TNI and PCT andthe proportions of those abnormal indicators in critical patients were significantly higher than those in severepatients（all P < 0.05）. Lastly，logistic regression analysis showed that the severity of COVID⁃19 was positivelycorrelated with the increase of hs⁃TNI，LDH，CRP，and PCT（P < 0.05）. Correlation analysis showed that hs⁃TNIwas positively correlated with CRP（r = 0.49，P < 0.001）and PCT（r = 0.318，P = 0.033），CK⁃MB was positivelycorrelated with CRP（r = 0.388，P = 0.002）and PCT（r = 0.264，P = 0.047），LDH was positively related to CRP（r = 0.349，P = 0.005）. Conclusions Among patients with Severe/critical COVID⁃19，old age and a history ofcardiovascular diseases are common，the severity of myocardial injury and inflammatory response are serious，andthe proportion is large. Moreover，the severity of myocardial injury is closely related to inflammatory response.

Key words: COVID?19, myocardial injury, inflammation