关键词: 早产儿, 颅内出血, 凝血功能, 血小板计数, 预测价值

Abstract:

Objective To analyze the correlation between intracranial hemorrhage and coagulation function， platelet count in preterm infants younger than 32 weeks. Methods A total of 101 preterm infants under 32 weeks who were admitted to Fuyang People's Hospital Affiliated to Anhui Medical University from May 2020 to July 2024 were selected. Within 3 days after birth， all the children were divided into the non-occurrence group （59 cases） and the occurrence group （42 cases） based on whether intracranial hemorrhage occurred in preterm infants less than 32 weeks.The influencing factors of intracranial hemorrhage in preterm infants less than 32 weeks was analyzed. he predictive value of coagulation function index and platelet count for intracranial hemorrhage in preterm infants less than 32 weeks was analyzed. Results The birth weight and gestational age of the occurrence group were lower than non-occurrence group （P < 0.05）.Fibrinogen （FIB） and D-dimer （D-D） in the occurrence group were higher than non-occurrence group （P < 0.05）， and the prothrombin time （PT） and activated partial thromboplastin time （APTT） in the occurrence group were longer than non-occurrence group （P < 0.05）， and platelet count in occurrence group was lower than non-occurrence group （P < 0.05）. FIB （OR = 4.272， 95%CI： 2.154 ? 8.472）， D-D （OR = 3.607， 95%CI： 1.819 ? 7.155）， APTT （OR = 3.056， 95%CI： 1.541 ? 6.060） was an independent risk factor for intracranial hemorrhage in preterm infants less than 32 weeks （P < 0.05）， and platelet count （OR = 0.282， 95%CI： 0.142 ? 0.560） was a protective factor for intracranial hemorrhage in preterm infants less than 32 weeks （P < 0.05）. The AUC values of FIB， D-D， APTT， platelet count and the combined prediction of intracranial hemorrhage in preterm infants less than 32 weeks were 0.799， 0.803， 0.845， 0.796 and 0.911， respectively （P < 0.05）， and the AUC values of the combined four groups were higher （P < 0.05）. Conclusion FIB， D-D， APTT and platelet count have important value in predicting intracranial hemorrhage in preterm infants less than 32 weeks， and the combined value of the four is higher.

Key words: premature infants, intracranial hemorrhage, coagulation function, platelet count, predictive value