实用医学杂志 ›› 2025, Vol. 41 ›› Issue (12): 1929-1935.doi: 10.3969/j.issn.1006-5725.2025.12.023

• 综述 • 上一篇    

嗜神经侵袭在妇科恶性肿瘤中的研究进展

何业坤,龙颖(),岑立仗,姚德生   

  1. 广西医科大学附属肿瘤医院妇瘤科 (广西 南宁 530021 )
  • 收稿日期:2025-01-13 出版日期:2025-06-25 发布日期:2025-07-02
  • 通讯作者: 龙颖 E-mail:longcljying@163.com
  • 基金资助:
    国家自然科学基金项目(81760466);广西自然科学基金项目(2022GXNSFBA035476)

Research progress of perineural invasion in gynecological malignant tumors

Yekun HE,Ying LONG(),Lizhang CEN,Desheng. YAO   

  1. Department of Gynecologic Oncology,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,Guangxi,China
  • Received:2025-01-13 Online:2025-06-25 Published:2025-07-02
  • Contact: Ying LONG E-mail:longcljying@163.com

摘要:

嗜神经侵袭(perineural invasion, PNI)作为恶性肿瘤的一种特殊病理因素与转移途径,与多个癌种的预后密切相关。近年来,PNI在妇科恶性肿瘤中的临床意义及机制研究逐渐受到关注。目前认为PNI与宫颈癌、外阴癌临床病理、预后相关;机制研究则涉及多个妇科肿瘤及多个分子通路,如CCL2/CCR2轴、NGF/TrkA通路、GluR2等,但研究模式碎片化,不够系统深入,需要整合。该文就PNI在妇科恶性肿瘤中的发生、与临床病理和预后的关系、对手术方式和术后辅助治疗的指导,以及可能的分子机制作一综述,通过整合临床和基础研究进展,旨在为妇科恶性肿瘤PNI的相关机制探索及临床治疗策略优化提供一定的理论依据。

关键词: 嗜神经侵袭, 宫颈癌, 外阴癌, 卵巢癌, 子宫内膜癌

Abstract:

As a distinct pathological factor and metastatic route of malignant tumors, perineural invasion (PNI) exhibits a close association with the prognosis of several cancer types. In recent years, the clinical significance and underlying mechanisms of PNI in gynecological malignant tumors have increasingly drawn research attention. Currently, it is recognized that PNI is clinicopathologically and prognostically linked to cervical cancer and vulvar cancer. The exploration of its mechanisms encompasses multiple gynecological tumors and numerous molecular pathways, including the CCL2/CCR2 axis, NGF/TrkA pathway, GluR2, among others. Nevertheless, the existing research models are fragmented, lacking systematicity and in-depth analysis, thus necessitating integration. This paper presents a comprehensive review of the occurrence of PNI in gynecologic malignancies, its correlations with clinicopathology and prognosis, its implications for surgical approaches and postoperative adjuvant therapies, as well as the potential molecular mechanisms. By synthesizing the advancements in both clinical and basic research, this review aims to offer a solid theoretical foundation for further exploration of the mechanisms underlying PNI in gynecologic malignancies and for the optimization of clinical therapeutic strategies.

Key words: perineural invasion, cervical cancer, vulvar carcinoma, ovarian cancer, endometrial cancer

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