实用医学杂志 ›› 2021, Vol. 37 ›› Issue (13): 1774-1778.doi: 10.3969/j.issn.1006⁃5725.2021.13.027

• 综述 • 上一篇    

miR⁃124 在结直肠癌的相关研究进展:一个潜在的治疗靶点#br#

张辉, 路明亮   

  1. 昆明医科大学第二附属医院消化内科(昆明 650000)

  • 出版日期:2021-07-10 发布日期:2021-07-10
  • 通讯作者: 路明亮 E⁃mail:lml19910@163.com
  • 基金资助:

    云南省卫生和计划生育委员会医学后备人才培养 计划(编号:H⁃201702


     

Progress of miR ⁃124 in colorectal cancer :a potential therapeutic target 

ZHANG Hui,LU Mingliang   

  1. Department of Gastroenterologythe Second Affiliated HospitalKunming Medical UniversityKunming 650000 China
  • Online:2021-07-10 Published:2021-07-10
  • Contact: LU Mingliang E⁃mail:lml19910@163.com

摘要:

结直肠癌(colorectal cancer,CRC)是常见的消化系统恶性肿瘤。随着人们生活方式的改变, CRC 的发病率和病死率在世界范围内逐年增高,结直肠癌的发生发展机制至今仍不清楚,复发率高、易转 移等生物学特性,导致预后差,是目前临床治疗面临的巨大挑战。miR⁃124 可影响结直肠癌的发生发展, 在结直肠癌发病机制方面已进行了深入研究;本文对 miR⁃124 上游调节分子、下游靶基因及潜在的 RNA 靶向治疗相关进展作一综述。

关键词:

miR?124,  , 结直肠癌,  , 靶向治疗

Abstract:

Colorectal cancer(CRC)is the most common carcinoma in gut. The incidence and mortality of CRC are increasing gradually every year with the changes of people′s life style,but the underlying mechanism is still not completely elucidated. The poor prognosis is due to its high rates of recurrence and metastasis. miR ⁃ 124 has been confirmed to play a vital role in the pathogenesis of CRC. In this review,we summarize the upstream mol⁃ ecules and downstream target genes of miR⁃124,and we also discuss the potential target therapy for miR⁃124

Key words:

 , miR?124, colorectal cancer, target therapy