实用医学杂志 ›› 2022, Vol. 38 ›› Issue (10): 1276-1279.doi: 10.3969/j.issn.1006⁃5725.2022.10.020

• 医学检查与临床诊断 • 上一篇    下一篇

血清miR⁃134及miR⁃301水平对慢性丙型肝炎肝纤维化的诊断价值

陈永刚1 黄刚2    

  1. 陕西中医药大学附属医院 1 输血科,2 检验科(陕西咸阳 712000)

  • 出版日期:2022-05-25 发布日期:2022-05-25
  • 通讯作者: 黄刚 E⁃mail:yonggangchen1998@163.com
  • 基金资助:
    2020年陕西省重点研发计划项目(编号:2020SF⁃177)

Diagnostic value of serum miR ⁃134 and miR ⁃301 level in liver fibrosis in patients with chronic hepatitis C

CHEN Yonggang*,HUANG Gang.   

  1. Department of Blood Transfusion Branch,Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China

  • Online:2022-05-25 Published:2022-05-25
  • Contact: HUANG Gang E⁃mail:yonggangchen1998@163.com

摘要:

目的 探讨血清miR⁃134及miR⁃301水平对慢性丙型肝炎肝纤维化的诊断价值。方法 选取 我院收治的 150 例慢性丙型肝炎(chronic hepatitis C,CHC)患者为 CHC 组,同期从健康人群中选择 150 例为 对照组。比较两组ALT、AST、TBIL、miR⁃134及miR⁃301水平。将CHC组根据肝纤维化分期(S0⁃S4级)分为 不同亚组,比较亚组间各指标水平。采用ROC曲线分析ALT、AST、TBIL、miR⁃134及miR⁃301水平在诊断显 著性肝纤维化(S2⁃S4期)中的临床价值。结果 相较于对照组,CHC组ALT、AST、TBIL、miR⁃134及miR⁃301 水平显著上升(P < 0.05),且随肝纤维化分期增加,患者 ALT、AST、TBIL、miR⁃134 miR⁃301 水平有所上升 P < 0.05)。ROC曲线结果显示,ALT、AST、TBIL诊断显著性肝纤维化的AUC < 0.7,而miR⁃134及miR⁃301 平诊断显著性肝纤维化的AUC > 0.70。结论 慢性丙型肝炎患者血清miR⁃134及miR⁃301水平显著上升,并与患者肝纤维程度密切相关。miR⁃134、miR⁃301检测在诊断显著性肝纤维化中具有一定临床价值。

关键词:

慢性丙型肝炎,  , 肝纤维化,  , miR?134,  , miR?301

Abstract:

Objective To investigate the diagnostic value of serum miR ⁃ 134 and miR ⁃301 level in liver fibrosis in patients with chronic hepatitis C(CHC). Methods One hundred and fifty patients with CHC admitted to our hospital were selected as CHC group,and 150 healthy people as control group during the same period. The level of ALT,AST,TBIL,miR⁃134 and miR⁃301 was compared between the two groups. The CHC group was divided into different subgroups according to the liver fibrosis stage(S0 ⁃ S4 grade),and the level of various indexes among subgroups were compared. The ROC curve was used to analyze the clinical value of ALT,AST,TBIL,miR⁃134 and miR⁃301 level in the diagnosis of significant liver fibrosis(S2⁃S4 stage). Results Compared with that in the control group,the level of ALT,AST,TBIL,miR⁃134 and miR⁃301 in the CHC group increased significantly(P < 0.05). As the stage of liver fibrosis increased,the level of ALT,AST,TBIL,miR⁃134 and miR⁃301 increased(P < 0.05). ROC curve results showed that the AUC of ALT,AST,and TBIL in the diagnosis of significant liver fibrosis was < 0.7,while the AUC of miR ⁃ 134 and miR ⁃ 301 level in the diagnosis of significant hepatic fibrosis > 0.70. Conclusion The serum level of miR⁃134 and miR⁃301 in patients with CHC increases significantly,and is closely related to the degree of liver fibrosis in patients. The detection of miR⁃134 and miR⁃301 has certain clinical value in the diagnosis of significant liver fibrosis.

Key words: chronic hepatitis C,  , liver fibrosis,  , miR?134,  , miR?301