关键词: 胚胎停育, 染色体, 非整倍体, 高龄, 辅助生育, 自然受孕

Abstract:

Objective To explore the distribution of different types of chromosomal abnormality ofpatients diagnosed as embryo⁃stopping and analyze the risk factors leading to embryonic chromosome abnormality.Method To retrospectively analyze the clinical data of 536 patients diagnosed as embryo⁃stopping and treatedwith villus chromosome analysis in the Third Affiliated Hospital of Guangzhou Medical University from January2016 to June 2019 and analyze the distribution of villi chromosome abnormalities. Logistic regression analysis wasused to explore the risk factors of embryonic chromosomal abnormality. Results （1）The incidence of chromosomalabnormality in early embryo⁃stopping was 61.8%. Ttrisomy，triploid and（45，X）were the three common types ofabnormalities. Among the cases with abnormal chromosome structures，the more common type is deletion. Trisomy16（30.4%）and trisomy 22（21.9%）were the two more common in trisomy.（2）Advanced age was a risk factor forchromosomal abnormality，while assisted reproductive conception a protective factor. The incidence of abnormalchromosome number，aneuploidy，trisomy and compound trisomy in the group with age ≥ 35 were all significantlyhigher than those in the group with age ＜35（P < 0.05）. Chromosomal abnormality rate and triploid rate of theassisted reproductive conception group were significantly lower than those of the natural conception group（P < 0.05）.Conclusion Fetal chromosome abnormality is the main reason for early embryo⁃stopping. Trisomy and triploid and（45，X）are frequently⁃seen and among trisomies，trisomy 16 and trisomy 22 are the two more common. Age is pos⁃itively correlated with embryonic chromosome abnormality；assisted reproductive conception will not increase theincidence of embryonic chromosome abnormalities.

Key words: embryo?stopping, chromosome, aneuploid, advanced age, assisted reproduction, natural conception