实用医学杂志 ›› 2021, Vol. 37 ›› Issue (23): 3041-3046.doi: 10.3969/j.issn.1006⁃5725.2021.23.016

• 临床研究 • 上一篇    下一篇

夫妇双方不同乙型肝炎病毒感染模式对宫腔内人工授精妊娠结局及新生儿情况的影响

孙向茹1 蔡炳2 张丽丽1 刘海鹏1 罗杰鹏1 刘奇志1   

  1. 1 广州市番禺区妇幼保健院生殖医学科(广州 511400);2 中山大学附属第一医院生殖医学中心(广州 510080)

  • 出版日期:2021-12-10 发布日期:2021-12-10
  • 通讯作者: 刘奇志 E⁃mail:1009231360@qq.com
  • 基金资助:
    番禺区科技计划项目(编号:2019⁃204⁃46)

Influence of different HBV infection patterns of couples on pregnancy and neonatal outcomes in intrauter⁃ ine insemination

SUN Xiangru*,CAI Bing,ZHANG Lili,LIU Haipeng,LUO Jiepeng,LIU Qizhi.   

  1. Institute of Reproductive MedicinePanyu Maternal And Child Care Service Centre of GuangzhouGuangzhou 511400China
  • Online:2021-12-10 Published:2021-12-10
  • Contact: LIU Qizhi E⁃mail:1009231360@qq.com
  • Supported by:


摘要:

目的 探讨夫妇双方不同乙型肝炎病毒(hepatitis B virus,HBV)感染模式对 IUI 治疗后妊娠 结局及出生子代情况的影响。 方法 回顾性分析我院生殖中心2016年1月⁃2020年6月接受IUI治疗的周期, 根据夫妇双方 HBsAg 是否为阳性分为 4 组:A 组,仅男方 HBsAg 阳性;B 组,仅女方 HBsAg 阳性;C 组,双方 HBsAg均阳性;D组(对照组),双方HBsAg均阴性。比较四组间基本资料、临床结局及出生婴儿情况的差异。 结果 不同HBV 感染模式组妊娠结局与对照组相比差异无统计学意义。出生子代情况方面,男方HBV 染组婴儿剖宫产率高于对照组(67.3% vs. 46.7%,P = 0.010),出生婴儿的男女比例高于对照组[(39∶14)vs. (107∶89),P = 0.013)]。女方及双方 HBV 感染组出生子代情况与对照组相比无差异。所有出生子代 均无畸形及 HBV 感染。结论 IUI 助孕治疗中夫妇双方或一方 HBV 感染可能不会对妊娠结局产生不利 影响,但是男方HBV 感染可能增加子代的剖宫产率,并且可能对出生婴儿的性别产生一定的影响。

关键词:

不同HBV 感染模式, 宫腔内人工授精, 妊娠结局, 出生婴儿情况

Abstract:

Objective To investigate different HBV infection patterns of couples on the pregnancy and neonatal outcomes in the intrauterine insemination(IUI). Methods A retrospective analysis of IUI treatment from January 2016 to June 2020 in Reproductive Medicine Center in our hospital was conducted. According to whether HBsAg was seropositive or not,the patients were divided into group A(male partners being HBV+);group B (female partners being HBV+);group C(both partners being HBV+)and group D(controls,both partners being HBV⁃seronegative). The differences of basic parameters,clinical pregnancy and neonatal outcomes among the four groups were compared. Results Compared with that in the control group,there was no difference in pregnancy outcomes in group A,B and C. In terms of the neonatal outcomes,we found the cesarean rate was significantly higher in group A when compared with the control group(67.3% vs. 46.7%,P = 0.010). Moreover,the sex ratio of offspring in group A was statistically higher than that in the control group[(39∶14)vs.(107∶89),P = 0.013]. However,there was no difference between group B or C and the control group. All offspring were no deforming and free of HBV infection. Conclusion Different HBV infection patterns of couples have no effect on pregnancy out⁃ comes. However,male partners being HBV infection may increase the risk of cesarean rate,and has certain effect on the sex ratio of newborns.

Key words:

different HBV infection patterns, intrauterine insemination, pregnancy outcome, neonatal outcome