实用医学杂志 ›› 2020, Vol. 36 ›› Issue (24): 3353-3357.doi: 10.3969/j.issn.1006⁃5725.2020.24.010

• 临床研究 • 上一篇    下一篇

平均血小板体积/淋巴细胞比值与冠心病经皮冠状动脉介入治疗术后长期死亡率的关系:一项队列研究

宋风华,郑颖颖,唐俊楠,郭倩倩,张建朝,程梦蝶,蒋丽珠,王凯,刘志煜,柏岩,张金盈
  

  1. 1 郑州大学第一附属医院心血管内科(郑州 450052);2 河南省心脏损伤修复重点实验室(郑州 450052)
  • 出版日期:2020-12-25 发布日期:2021-01-19
  • 通讯作者: 张金盈 E⁃mail:jyzhang@zzu.edu.cn
  • 基金资助:
    国家自然科学基金(编号:81570274,81870328,81800267);校院联合基金(编号:2016⁃BSTDJJ⁃19)

Association of mean platelet volume to lymphocyte ratio with long ⁃ term mortality after PCI in coronary heart disease:a cohort study

SONG Fenghua,ZHENG Yingying,TANG Junnan,GUO Qianqian,ZHANG Jianchao,CHENG Mengdie,JIANG Lizhu,WANG Kai,LIU Zhiyu,BAI Yan,ZHANG Jinying.   

  1. Department of Cardiovascular Medicine,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,China;*He′nan
    Key Laboratory of Heart Injury Repair,Zhengzhou 450052,China
  • Online:2020-12-25 Published:2021-01-19
  • Contact: ZHANG Jinying E⁃mail:jyzhang@zzu.edu.cn

摘要:

目的 探究血小板体积与淋巴细胞比值(MPVLR)与冠心病经皮冠状动脉介入(PCI)术后患 者长期死亡率的相关性。方法 筛选 2013 1 月至 2017 12 月就诊于郑州大学第一附属医院心内科行 PCI 术的冠心病患者 3 472 例,根据 ROC 曲线确定 MPVLR 预测冠心病 PCI 术后患者长期死亡率的最佳临 界值为 5.69,根据临界值水平将分为低 MPVLR 组(MPVLR < 5.69,n = 2 433)和高 MPVLR 组(MPVLR ≥ 5.69,n = 1 039)。结果 单因素分析显示两组间全因死亡及心源性死亡在两组之间有统计学差异(P < 0.05);Cox 多因素回归分析显示:入院时高 MPVLR 是冠心病患者 PCI 术后长期心源性死亡(HR = 1.630 95%CI:1.020 ~ 2.640,P < 0.05)及全因死亡(HR = 1.579,95%CI:1.093 ~ 2.281,P < 0.05)的独立危险因素。 高MPVLR 对于冠心病患者PCI 术后长期死亡事件有一定预测价值。

关键词:

Abstract:

Objective To investigate the association of mean platelet volume to lymphocyte ratio(MPVLR with long ⁃ term mortality in patients with coronary heart disease after percutaneous coronary intervention(PCI). Methods From January 2013 to December 2017,3 472 patients with coronary heart disease undergoing PCI in our hospital were enrolled. Based on receiver operating characteristics curve analysis,the best threshold value for predicting long⁃term mortality in patients with coronary heart disease after PCI was 5.69. According to the threshold value,the patients were divided into the low MPVLR(MPVLR < 5.69,n = 2 433)and the high MPVLR group (MPVLR ≥ 5.69,n = 1 039). Results Inunivariate analysis,there was a significant difference in all⁃cause death and cardiogenic death between the two groups(P < 0.05);Cox multivariate regression analysis showed that higher MPVLR level in admission was an independent risk factor for long⁃term cardiogenic death(HR = 1.630,95%CI 1.020 ~ 2.640,P < 0.05)and all⁃cause death(HR = 1.579,95%CI:1.093 ~ 2.281,P < 0.05)in patients with coronary heart disease after PCI. Conclusions MPVLR has certain predictive value for long⁃term death events in patients with coronary heart disease after PCI.

Key words: