实用医学杂志 ›› 2020, Vol. 36 ›› Issue (24): 3349-3352.doi: 10.3969/j.issn.1006⁃5725.2020.24.009

• 临床研究 • 上一篇    下一篇

不同体质量指数慢性阻塞性肺疾病急性加重期老年患者肺功能及血清细胞因子水平的差异

陈淑娟,闻立新,金兵,刘锦铭,吴浩
  

  1. 1 苏州大学附属常州肿瘤医院(常州市第四人民医院)呼吸科(江苏常州 213001);2 同济大学附属上海市肺科医院肺循环科(上海 200433);3 上海市浦东新区人民医院呼吸科(上海 201299)
  • 出版日期:2020-12-25 发布日期:2021-01-19
  • 基金资助:
    中华医学会临床医学科研专项资金项目(编号:08020420120);江苏省卫生计生委科研课题资助项目(编号:H20150756)

Pulmonary function COPD serum cytokine levels in aged patients with different BMI indices and acute exacerbation

CHEN Shujuan,WEN Lixin,JIN Bing,LIU Jinming,WU Hao
  

  1. Changzhou Cancer HospitalAffiliated to Soochow University(Changzhou Fourth People′s Hospital Respiratory),Changzhou 213001,China
  • Online:2020-12-25 Published:2021-01-19

摘要:

目的 探讨不同体质量指数(BMI)慢性阻塞性肺疾病(COPD)急性加重期老年患者肺功能及 血清细胞因子水平的差异,分析 BMI 与肺功能及血清细胞因子表达水平的关系。方法 选取 2018 6 2019 12 月我院收治的急性加重期 COPD 老年患者 97 例作为研究对象,根据 BMI 分为三组:正常体质 量组(31 例),低体质量组(32 例),高体质量组(34 例)。测定所有受试者血清细胞因子水平、血气指标、 肺功能指标。采用 Pearson 相关性分析分析 BMI COPD 急性加重期老年患者肺功能及血清细胞因子水 平的相关性。结果 BMI COPD 急性加重期老年患血清细胞因子水平呈负相关,与肺功能指标呈正相 关。结论 BMI COPD 急性加重期老年患者肺功能及炎症反应指标具有相关性,能够一定程度上评估 患者病情的严重程度。

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Abstract:

Objective To investigate the difference of lung function and serum cytokine levels in elderly patients diagnosed with COPD with different BMI with acute exacerbation. To analyze the relationship between BMI and lung function and the level of serum cytokine expression. Methods A total of 97 elderly patients with acute exacerbation of COPD admitted to our hospital from June 2018 to December 2019 were selected as the research objects. They were divided into three groups according to BMI:normal body reconstitution(31 cases),low body reconstitution(32 cases),and high body reorganization(34 cases). The serum cytokine levels,blood gas indexes and lung function indexes of all subjects were determined. Pearson correlation was used to analyze the correlation between BMI and lung function and serum cytokine levels in elderly patients with acute exacerbation of COPD. Results BMI was negatively correlated with serum cytokine levels in elderly patients with acute exacerbation of COPD and positively correlated with lung function. Conclusion BMI is correlated with pulmonary function and inflammatory response index in elderly patients with acute exacerbation of COPD,which can evaluate the severity of the disease to a certain extent.

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