The Journal of Practical Medicine >
Research progress of biomarkers in the monitoring of vitiligo stages
Received date: 2025-07-01
Online published: 2025-09-05
Vitiligo is a common depigmentation skin disorder, characterized by hypopigmented or depigmented patches on the skin or mucous membranes. The disease can be classified into two stages: the active stage and the stable stage. Accurately determining the disease stage is crucial for developing an appropriate treatment plan. However, there is currently no standardized biological marker to assess the disease stage. This article reviews the progress of research on biological markers for different stages of vitiligo.
Key words: vitiligo; biology; markers; disease stage
Lu CAO , Haiyan TU , Yang ZHAO . Research progress of biomarkers in the monitoring of vitiligo stages[J]. The Journal of Practical Medicine, 2025 , 41(17) : 2767 -2771 . DOI: 10.3969/j.issn.1006-5725.2025.17.023
| [1] | PEREZ-BOOTELLO J, COVA-MARTIN R, NAHARRO-RODRIGUEZ J, et al. Vitiligo: Pathogenesis and New and Emerging Treatments[J]. Int J Mol Sci, 2023, 24(24):17306. doi:10.3390/ijms242417306 |
| [2] | RAMOT Y, ROSENBERG V, ZHOU L, et al. Epidemiology and Treatment Patterns of Patients with Vitiligo: A Real-World Analysis[J]. Adv The, 2024, 41(7):2890-2906. doi:10.1007/s12325-024-02875-0 |
| [3] | BELLEI B, PAPACCIO F, PICARDO M. Regenerative Medicine-Based Treatment for Vitiligo: An Overview[J]. Biomedicines, 2022,10(11):2744. doi:10.3390/biomedicines10112744 |
| [4] | JOGE R R, KATHANE P U, JOSHI S H. Vitiligo: A Narrative Review[J]. Cureus, 2022, 14(9):e29307. |
| [5] | 曹露, 赵阳. 皮肤移植治疗稳定期白癜风的研究进展[J]. 实用医学杂志, 2025,41(2):300-304. |
| [6] | YADAV A K, SINGH P, KHUNGER N. Clinicopathologic Analysis of Stable and Unstable Vitiligo: A Study of 66 Cases[J]. Am J Dermatopathol, 2016, 38(8):608-613. doi:10.1097/dad.0000000000000539 |
| [7] | ABDALLAH M, LOTFI R, OTHMAN W, et al. Assessment of tissue FoxP3+, CD4+ and CD8+ T-cells in active and stable nonsegmental vitiligo[J]. Int J Dermatol, 2014, 53(8):940-946. doi:10.1111/ijd.12160 |
| [8] | STRASSNER J P, RASHIGHI M, AHMED R M, et al. Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity[J]. J Am Acad Dermatol, 2017, 76(5):847-855. doi:10.1016/j.jaad.2016.12.021 |
| [9] | ZHANG B, LI T, TANG Y, et al. The effects of 308-nm excimer laser on the infiltration of CD4+, CD8+ T-cells, and regulatory T cells in the lesional skin of patients at active and stable stages of nonsegmental vitiligo[J]. J Dermatolog Treat, 2021, 32(6):580-584. doi:10.1080/09546634.2019.1687825 |
| [10] | NG C Y, CHAN Y P, CHIU Y C, et al. Targeting the elevated IFN-γ in vitiligo patients by human anti- IFN-γ monoclonal antibody hampers direct cytotoxicity in melanocyte[J]. J Dermatol Sci, 2023, 110(3):78-88. doi:10.1016/j.jdermsci.2023.04.006 |
| [11] | LIN F, HU W, XU W, et al. CXCL9 as a key biomarker of vitiligo activity and prediction of the success of cultured melanocyte transplantation[J]. Sci Rep, 2021, 11(1):18298. doi:10.1038/s41598-021-97296-2 |
| [12] | MARCHIORO H Z, SILVA DE CASTRO C C, FAVA V M, et al. Update on the pathogenesis of vitiligo[J]. An Bras Dermatol, 2022,97(4):478-490. doi:10.1016/j.abd.2021.09.008 |
| [13] | DOSS R W, EL-RIFAIE A A, ABDEL-WAHAB A M, et al. Heat Shock Protein-70 Expression in Vitiligo and its Relation to the Disease Activity[J]. Indian J Dermatol, 2016, 61(4):408-412. doi:10.4103/0019-5154.185704 |
| [14] | OCHOA-RAMíREZ L A, DíAZ-CAMACHO S P, MELLADO-CORRALES S N, et al. Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients[J]. Int J Dermatol, 2023, 62(2):225-230. doi:10.1111/ijd.16487 |
| [15] | FEGHAHATI F S, GHAFOURI-FARD S. A comprehensive outline of the role of non-coding RNAs in vitiligo[J]. Biochem Biophys Rep, 2025,41:101916. doi:10.1016/j.bbrep.2025.101916 |
| [16] | ?AHMATOVA L, TANKOV S, PRANS E, et al. MicroRNA-155 is Dysregulated in the Skin of Patients with Vitiligo and Inhibits Melanogenesis-associated Genes in Melanocytes and Keratinocytes[J]. Acta Derm Venereol, 2016,96(6):742-747. |
| [17] | BRAHMBHATT H D, GUPTA R, GUPTA A, et al. The long noncoding RNA MALAT1 suppresses miR-211 to confer protection from ultraviolet-mediated DNA damage in vitiligo epidermis by upregulating sirtuin 1[J]. Br J Dermatol, 2021, 184(6):1132-1142. doi:10.1111/bjd.19666 |
| [18] | MANSURI M S, SINGH M, DWIVEDI M, et al. MicroRNA profiling reveals differentially expressed microRNA signatures from the skin of patients with nonsegmental vitiligo[J]. Br J Dermatol, 2014, 171(5):1263-1267. doi:10.1111/bjd.13109 |
| [19] | ABDALLAH M, EL-MOFTY M, ANBAR T, et al. CXCL-10 and Interleukin-6 are reliable serum markers for vitiligo activity: A multicenter cross-sectional study[J]. Pigment Cell Melanoma Res, 2018, 31(2):330-336. doi:10.1111/pcmr.12667 |
| [20] | UTTMANI B M, ADYA K A, INAMADAR A C. Serum interleukin-6 and high sensitivity C-reactive protein levels and their correlation with the vitiligo disease activity and extent: A cross-sectional study of 58 patients[J]. J Cutan Aesthet Surg, 2024, 17(3):266-271. |
| [21] | BELPAIRE A, VAN GEEL N, SPEECKAERT R. From IL-17 to IFN-γ in inflammatory skin disorders: Is transdifferentiation a potential treatment target?[J]. Front Immunol, 2022, 13:932265. doi:10.3389/fimmu.2022.932265 |
| [22] | BERNARDINI N, SKROZA N, TOLINO E, et al. IL-17 and its role in inflammatory, autoimmune, and oncological skin diseases: state of art[J]. Int J Dermatol, 2020,59(4):406-411. doi:10.1111/ijd.14695 |
| [23] | NIERADKO-IWANICKA B, PRZYBYLSKA D, BORZ?CKI A. A case-control study on immunologic markers of patients with vitiligo[J]. Biomed Pharmacother, 2022, 156:113785. doi:10.1016/j.biopha.2022.113785 |
| [24] | TOMASZEWSKA K, KOZ?OWSKA M, KASZUBA A, et al. Increased Serum Levels of IFN-γ, IL-1β, and IL-6 in Patients with Alopecia Areata and Nonsegmental Vitiligo[J]. Oxid Med Cell Longev, 2020, 2020:5693572. doi:10.1155/2020/5693572 |
| [25] | CUSTURONE P, DI BARTOLOMEO L, IRRERA N, et al. Role of Cytokines in Vitiligo: Pathogenesis and Possible Targets for Old and New Treatments[J]. Int J Mol Sci, 2021,22(21):11429. doi:10.3390/ijms222111429 |
| [26] | MAI Z M, BYRNE S N, LITTLE M P, et al. Solar UVR and Variations in Systemic Immune and Inflammation Markers[J]. JID Innov, 2021, 1(4):100055. doi:10.1016/j.xjidi.2021.100055 |
| [27] | HOSSAIN M R, ANSARY T M, KOMINE M, et al. Diversified Stimuli-Induced Inflammatory Pathways Cause Skin Pigmentation[J]. Int J Mol Sci, 2021, 22(8):3970. doi:10.3390/ijms22083970 |
| [28] | YANG L, YANG S, LEI J, et al. Role of chemokines and the corresponding receptors in vitiligo: A pilot study[J]. J Dermatol, 2018, 45(1):31-38. doi:10.1111/1346-8138.14004 |
| [29] | WANG X X, WANG Q Q, WU J Q, et al. Increased expression of CXCR3 and its ligands in patients with vitiligo and CXCL10 as a potential clinical marker for vitiligo[J]. Br J Dermatol, 2016, 174(6):1318-1326. doi:10.1111/bjd.14416 |
| [30] | ZHANG L, KANG Y, CHEN S, et al. Circulating CCL20: A potential biomarker for active vitiligo together with the number of Th1/17 cells[J]. J Dermatol Sci, 2019, 93(2):92-100. doi:10.1016/j.jdermsci.2018.12.005 |
| [31] | RICHMOND J M, MASTERJOHN E, CHU R, et al. CXCR3 Depleting Antibodies Prevent and Reverse Vitiligo in Mice[J]. J Invest Dermatol, 2017, 137(4):982-985. doi:10.1016/j.jid.2016.10.048 |
| [32] | AULAKH S, GOEL S, KAUR L, GULATI S, et al. Differential expression of serum CXCL9 and CXCL10 levels in vitiligo patients and their correlation with disease severity and stability: A cross-sectional study[J]. Indian J Dermatol Venereol Leprol, 2025, 91(1):9-15. doi:10.25259/ijdvl_793_2023 |
| [33] | ERDO?AN A, MUTLU H S, SOLAKO?LU S. Autologously transplanted dermis-derived cells alleviated monobenzone-induced vitiligo in mouse[J]. Exp Dermatol, 2022, 31(9):1355-1363. doi:10.1111/exd.14603 |
| [34] | CHALLA A, CHAUHAN S, PANGTI R, et al. Evaluation of clinical efficacy and laboratory indicators of non-cultured epidermal cell suspension and hair follicle cell suspension in surgical management of stable vitiligo: A randomized comparative trial[J]. J Cosmet Dermatol, 2022, 21(12):6958-6964. doi:10.1111/jocd.15407 |
| [35] | KAWAKAMI T. Surgical procedures and innovative approaches for vitiligo regenerative treatment and melanocytorrhagy[J]. J Dermatol, 2022, 49(4):391-401. doi:10.1111/1346-8138.16316 |
| [36] | HUO J, LIU T, LI F, et al. MicroRNA?21?5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo[J]. Mol Med Rep, 2021, 23(1):51. doi:10.3892/mmr.2020.11689 |
| [37] | AGUENNOUZ M, GUARNERI F, OTERI R, et al. Serum levels of miRNA-21-5p in vitiligo patients and effects of miRNA-21-5p on SOX5, beta-catenin, CDK2 and MITF protein expression in normal human melanocytes[J]. J Dermatol Sci, 2021, 101(1):22-29. doi:10.1016/j.jdermsci.2020.10.014 |
| [38] | SHI Q, ZHANG W, GUO S, et al. Oxidative stress-induced overexpression of miR-25: The mechanism underlying the degeneration of melanocytes in vitiligo[J]. Cell Death Differ, 2016, 23(3):496-508. doi:10.1038/cdd.2015.117 |
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