The Journal of Practical Medicine >
The role and research progress of miRNA in intestinal mucosal barrier function
Received date: 2024-11-18
Online published: 2025-04-23
The intestinal mucosal barrier plays a pivotal role in both innate and adaptive immune regulation. Its integrity is essential for maintaining overall health， as it acts as a critical interface between the luminal contents and the host immune system. MicroRNAs （miRNAs）， which are small noncoding RNAs， function as potent genetic regulators by interacting with multiple target genes to modulate entire cellular pathways. Recent studies have demonstrated that miRNAs are intricately involved in regulating the function of the intestinal mucosal barrier. This review examines the role of miRNAs in the intestinal mucosal barrier， encompassing their mechanisms， relevant clinical research findings， and potential directions for future investigation， to elucidate the potential value of miRNAs in the pathogenesis， diagnosis， and treatment of related diseases.
Key words： miRNA; intestinal mucosal barrier; IECs
Bangrong XU , Zhenghua JIANG , Xin CHEN , Jun CHEN , Haibo LUO , Daoming LIANG . The role and research progress of miRNA in intestinal mucosal barrier function[J]. The Journal of Practical Medicine, 2025 , 41(7) : 1079 -1083 . DOI: 10.3969/j.issn.1006-5725.2025.07.022
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