The Journal of Practical Medicine >

2025 , Vol. 41 >Issue 4: 561 - 568

DOI: https://doi.org/10.3969/j.issn.1006-5725.2025.04.015

Clinical Research

Efficacy of HP in series with CRRT integrated combined blood purification under extracorporeal citrate anticoagulation in the treatment of severe HTG⁃AP

  • Le WU ,
  • Runlu GENG ,
  • Jingjiang ZHOU ,
  • Li LI ,
  • Lei XU ,
  • Jie KANG ,
  • Bin LU ,
  • Ying YE ,
  • Hongning YANG ,
  • Weichao. DING
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  • *.Department of Emergency Medicine，the Affiliated Hospital of Xuzhou Medical University，Xuzhou 221002，Jiangsu，China
    *.Graduate School，Xuzhou Medical University，Xuzhou 221002，Jiangsu，China
    *.Jiangsu Provincial Institute of Health Emergency，Xuzhou 221002，Jiangsu，China

Received date: 2024-11-25

  Online published: 2025-02-28

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Abstract

Objective To study the efficacy of hemoperfusion （HP） in series with continuous renal replacement therapy （CRRT） integrated combined blood purification under extracorporeal citrate anticoagulation in the treatment of severe hypertriglyceridemic acute pancreatitis （HTG-AP）. Methods A total of 62 patients with severe HTG-AP admitted to the Affiliated Hospital of Xuzhou Medical University from June 2022 to May 2024 were selected and randomly divided into control group and observation group， with 31 cases in each group. The control group was treated with conventional medical treatment + HP combined with CRRT staged combined blood purification treatment， and the observation group was treated with conventional medical treatment + HP in series with CRRT integrated combined blood purification treatment under extracorporeal citrate anticoagulation. The indexes and clinical efficacy before and 7 days after treatment were compared between the two groups. Results The single CRRT time of the observation group was longer than that of the control group， and the frequency of CRRT was less than that of the control group （P < 0.05）. There were no significant differences in the total CRRT time， single HP time， HP frequency and total HP time between the two groups （P > 0.05）. The blood routine， inflammatory factors， blood biochemistry and clinical scores of the two groups after treatment were improved compared with those before treatment （P < 0.05）. After treatment， the hemoglobin（Hb） and platelet count（Plt） of the observation group were higher than those of the control group （P < 0.05）， and there were no significant differences in other indexes of blood routine， inflammatory factors， blood biochemistry and clinical scores between the two groups （P > 0.05）. There were no significant differences in clinical indexes， prognosis and complications between the two groups （P > 0.05）. Conclusions Without affecting the efficacy， HP in series with CRRT integrated combined blood purification under extracorporeal citrate anticoagulation in the treatment of severe HTG-AP can prolong the use time of CRRT blood filter and pipeline， reduce the use of consumables， reduce the risk of bleeding， and avoid multiple catheter removal of HP and CRRT operation separately， and reduce the risk of related infection. It is worthy of clinical application.

Key words： hemoperfusion; continuous renal replacement therapy; extracorporeal citrate anticoagulation; severe hypertriglyceridemic acute pancreatitis （HTG-AP）

Cite this article

Le WU , Runlu GENG , Jingjiang ZHOU , Li LI , Lei XU , Jie KANG , Bin LU , Ying YE , Hongning YANG , Weichao. DING . Efficacy of HP in series with CRRT integrated combined blood purification under extracorporeal citrate anticoagulation in the treatment of severe HTG⁃AP[J]. The Journal of Practical Medicine, 2025 , 41(4) : 561 -568 . DOI: 10.3969/j.issn.1006-5725.2025.04.015

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