The Journal of Practical Medicine >
Expression level of neutrophil/lymphocyte ratio and monocyte/high density lipoprotein cholesterol ratio in patients with sudden deafness and their correlation with prognosis
Received date: 2024-07-26
Online published: 2024-12-23
Objective To explore the correlation between neutrophil/lymphocyte ratio （NLR） and monocyte/high density lipoprotein cholesterol ratio （MHR） and the onset and prognosis of sudden deafness （SSNHL）. Methods 138 patients with sudden deafness who were treated in the hospital from January 2022 to May 2024 were selected as the study group， and 116 normal healthy people were selected as the control group. The changes of NLR and MHR in two groups and different types of SSNHL patients were compared. Logistic regression was used to explore the prognostic factors of patients with SSNHL. Results NLR and MHR in the study group were significantly higher than those in the control group （P < 0.05）. There were statistical differences in the average hearing threshold， total cholesterol （TC）， fibrinogen （FIB）， platelet count （PLT）， cortisol （COR）， NLR and MHR in patients with different types of SSNHL （P < 0.05）. NLR， MHR and SSNHL were significantly correlated （P < 0.05）. The increase of NLR and MHR is a risk factor for poor prognosis in patients with SSNHL. Conclusion NLR and MHR are closely related to the pathogenesis of SSNHL and are important factors leading to poor prognosis of patients with SSNHL.
Hongmei ZHU , Yongjiu HUANG , Jiusheng CHU , Xiuhong. PANG . Expression level of neutrophil/lymphocyte ratio and monocyte/high density lipoprotein cholesterol ratio in patients with sudden deafness and their correlation with prognosis[J]. The Journal of Practical Medicine, 2024 , 40(24) : 3503 -3508 . DOI: 10.3969/j.issn.1006-5725.2024.24.011
| 1 | TRIPATHI P， DESHMUKH P. Sudden Sensorineural Hearing Loss： A Review［J］. Cureus， 2022， 14（9）：e29458. |
| 2 | PRINCE A D P， STUCKEN E Z. Sudden Sensorineural Hearing Loss： A Diagnostic and Therapeutic Emergency［J］. J Am Board Fam Med， 2021， 34（1）：216-223. doi:10.3122/jabfm.2021.01.200199 |
| 3 | WANG Y， ZHANG Z H， LIAN W. Sudden Sensorineural Hearing Loss after Pituitary Adenoma Resection-A Case Series with Literature Review［J］. Chin Med Sci J， 2021， 36（2）：120-126. |
| 4 | CHEN J， ZHANG X， RATHJEN J P， et al. Direct recognition of pathogen effectors by plant NLR immune receptors and downstream signalling［J］. Essays Biochem， 2022， 66（5）：471-483. doi:10.1042/ebc20210072 |
| 5 | TSUZUKI N， WASANO K. Idiopathic sudden sensorineural hearing loss： A review focused on the contribution of vascular pathologies［J］. Auris Nasus Larynx， 2024， 51（4）：747-754. doi:10.1016/j.anl.2024.05.009 |
| 6 | 常晨阳， 胡绍雯， 邓国平， 等. 中性粒细胞计数与淋巴细胞和血小板计数比值在儿童脓毒症预后中的预测价值［J］. 实用医学杂志， 2023， 39（22）：2958-2963. doi:10.3969/j.issn.1006-5725.2023.22.017 |
| 7 | BILIK M Z， OYLUMLU M， OYLUMLU M， et al. Novel predictor of pulmonary arterial hypertension： Monocyte to HDL cholesterol ratio［J］. Medicine （Baltimore）， 2022， 101（34）：e29973. doi:10.1097/md.0000000000029973 |
| 8 | 中华耳鼻咽喉头颈外科杂志编辑委员会， 中华医学会耳鼻咽喉头颈外科学分会. 突发性聋诊断和治疗指南（2015）［J］. 中华耳鼻咽喉头颈外科杂志， 2015， 50（6）：443-447. |
| 9 | YANG S， LIU C， ZHAO C， et al. Pregnant Patients with Sudden Sensorineural Hearing Loss： Treatments and Efficacy［J］. J Int Adv Otol， 2023， 19（6）：472-277. doi:10.5152/iao.2023.22981 |
| 10 | LIU Y， ZENG Z， ZHANG Y M， et al. An angiosperm NLR Atlas reveals that NLR gene reduction is associated with ecological specialization and signal transduction component deletion［J］. Mol Plant， 2021， 14（12）：2015-2031. doi:10.1016/j.molp.2021.08.001 |
| 11 | KATIPO?LU Z， MIRZA E， OLTULU R，et al. May Monocyte/HDL Cholesterol Ratio （MHR） and Neutrophil/Lymphocyte Ratio （NLR） Be an Indicator of Inflammation and Oxidative Stress in Patients with Keratoconus？［J］. Ocul Immunol Inflamm，2020，28（4）：632-636. doi:10.1080/09273948.2019.1611876 |
| 12 | SIMANI L， ORON Y， SHAPIRA U， et al. Is Idiopathic Sudden Sensorineural Hearing Loss Seasonal？［J］. Otol Neurotol， 2022， 43（9）：1016-1021. doi:10.1097/mao.0000000000003661 |
| 13 | LI K H， CHIEN C Y， TAI S Y， et al. Prognosis Prediction of Sudden Sensorineural Hearing Loss Using Ensemble Artificial Intelligence Learning Models［J］. Otol Neurotol， 2024， 45（7）：759-764. doi:10.1097/mao.0000000000004241 |
| 14 | NITTA Y， KURIOKA T， FURUKI S， et al. Effect of statins on hearing outcome in patients with idiopathic sudden sensorineural hearing loss［J］. Laryngoscope Investig Otolaryngol， 2023， 8（6）：1631-1636. doi:10.1002/lio2.1170 |
| 15 | CHAUSHU H， UNGAR O J， ABU ETA R， et al. Spontaneous recovery rate of idiopathic sudden sensorineural hearing loss： A systematic review and meta-analysis［J］. Clin Otolaryngol， 2023， 48（3）：395-402. doi:10.1111/coa.14036 |
| 16 | LIU L， CHEN Y， XIE J. Association of GNRI， NLR， and FT3 with the Clinical Prognosis of Older Patients with Heart Failure［J］.Int Heart J， 2022，63（6）： 1048- 1054. doi:10.1536/ihj.22-306 |
| 17 | SALZANO G， DELL'AVERSANA ORABONA G， ABBATE V， et al. The prognostic role of the pre-treatment neutrophil to lymphocyte ratio （NLR） and tumor depth of invasion （DOI） in early-stage squamous cell carcinomas of the oral tongue［J］. Oral Maxillofac Surg， 2022，26（1）：21-32. doi:10.1007/s10006-021-00969-5 |
| 18 | ACAR B， YAYLA C， GUL M， et al. Monocyte-to-HDL-cholesterol ratio is associated with Ascending Aorta Dilatation in Patients with Bicuspid Aortic Valve［J］. Afr Health Sci， 2021， 21（1）：96-104. doi:10.4314/ahs.v21i1.14 |
| 19 | SUN Y， LU J， ZHENG D， et al. Predictive value of monocyte to HDL cholesterol ratio for stroke-associated pneumonia in patients with acute ischemic stroke［J］. Acta Neurol Belg， 2021， 121（6）：1575-1581. doi:10.1007/s13760-020-01418-y |
| 20 | H?RA ?， YA?AR M， KAYA A， et al. Prognostic Value of Fibrinogen/HDL Ratio in Idiopathic Sudden Sensorineural Hearing Loss［J］. J Int Adv Otol， 2021， 17（2）：91-95. |
| 21 | HUANG Z， FU Z， HUANG W， et al. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis： A meta-analysis［J］. Am J Emerg Med， 2020， 38（3）：641-647. doi:10.1016/j.ajem.2019.10.023 |
| 22 | 吴玲红， 周敏， 卢瑶， 等. 中性粒细胞/淋巴细胞比值及其变化值对肝细胞癌介入术后急性肝功能恶化风险的预测价值［J］. 实用医学杂志，2023，39（6）：713-718. |
| 23 | 王夏芹，何非，王同，等.中性粒细胞/淋巴细胞比率对预测不稳定心绞痛患者冠脉病变严重程度和临床风险的意义［J］.中国临床药理学与治疗学，2019，24 （3）：296-300. doi:10.12092/j.issn.1009-2501.2019.03.010 |
| 24 | DOO J G， KIM D， KIM Y， et al. Biomarkers Suggesting Favorable Prognostic Outcomes in Sudden Sensorineural Hearing Loss［J］. Int J Mol Sci， 2020， 21（19）：7248. doi:10.3390/ijms21197248 |
| 25 | LI J， QIU Z， QIU Y， et al. Prognostic Factors Influencing the Tinnitus Improvement After Idiopathic Sudden Sensorineural Hearing Loss Treatment［J］. Otol Neurotol， 2022， 43（6）：e613-e619. doi:10.1097/mao.0000000000003546 |
| 26 | SCIANCALEPORE P I， DE ROBERTIS V， SARDONE R， et al. Sudden sensorineural hearing loss： What factors influence the response to therapy？［J］. Audiol Res， 2020， 10（1）：234. doi:10.4081/audiores.2020.234 |
| 27 | NISHIMURA T， OKAYASU T， MORIMOTO C， et al. Evaluation of the Recovery of Idiopathic Sudden Sensorineural Hearing Loss Based on Estimated Hearing Disorders［J］. Audiol Res， 2022， 12（5）：476-484. doi:10.3390/audiolres12050048 |
/
| 〈 |
|
〉 |