The Journal of Practical Medicine >
Dual role and new strategies of pyroptosis in cancer therapy
Received date: 2024-09-02
Online published: 2024-12-16
Pyroptosis is a form of programmed cell death with inflammatory characteristics， which has attracted wide attention in the biomedical field in recent years. Pyroptosis plays a crucial role in activating host defenses， promoting inflammatory responses， regulating immune responses， and influencing the tumor microenvironment. In cancer research， the dual role of pyroptosis is particularly significant， which can both inhibit tumor growth and promote tumor development in certain instances. Furthermore， research on pyroptosis offers new perspectives for cancer treatment， particularly in enhancing the efficacy of traditional chemoradiotherapy， boosting anti-tumor immune responses， and applying nanotherapeutic strategies. This article reviews the regulatory role of pyroptosis in cancer progression， as well as its theoretical basis and practical applications as a potential anti-cancer strategy， with the aim of providing new insights and directions for the development of cancer treatment strategies in the future.
Xiao XIAO , Fangyi LONG , Gang. WANG . Dual role and new strategies of pyroptosis in cancer therapy[J]. The Journal of Practical Medicine, 2024 , 40(23) : 3419 -3426 . DOI: 10.3969/j.issn.1006-5725.2024.23.022
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