细胞焦亡在癌症治疗中的双重作用与新策略

doi:10.3969/j.issn.1006-5725.2024.23.022

Abstract

Abstract:

Pyroptosis is a form of programmed cell death with inflammatory characteristics， which has attracted wide attention in the biomedical field in recent years. Pyroptosis plays a crucial role in activating host defenses， promoting inflammatory responses， regulating immune responses， and influencing the tumor microenvironment. In cancer research， the dual role of pyroptosis is particularly significant， which can both inhibit tumor growth and promote tumor development in certain instances. Furthermore， research on pyroptosis offers new perspectives for cancer treatment， particularly in enhancing the efficacy of traditional chemoradiotherapy， boosting anti-tumor immune responses， and applying nanotherapeutic strategies. This article reviews the regulatory role of pyroptosis in cancer progression， as well as its theoretical basis and practical applications as a potential anti-cancer strategy， with the aim of providing new insights and directions for the development of cancer treatment strategies in the future.

Key words: pyroptosis, cancer progression promotion, tumor growth inhibition, chemoradiotherapy sensitivity enhancement, immune response modulation, nanomedicine

CLC Number:

R730.5

Xiao XIAO,Fangyi LONG,Gang. WANG. Dual role and new strategies of pyroptosis in cancer therapy[J]. The Journal of Practical Medicine, 2024, 40(23): 3419-3426.

Figures/Tables 1

References 69

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Dual role and new strategies of pyroptosis in cancer therapy

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