The Journal of Practical Medicine >
Research progress on chorioamnionitis and related neonatal diseases
Received date: 2024-08-27
Online published: 2024-12-16
Chorioamnionitis (CAM) refers to an inflammatory condition resulting from pathogen infection of the chorion, amnion, and decidua of the placenta. CAM is associated with preterm birth and an increased risk of adverse outcomes in neonates, including respiratory distress syndrome, bronchopulmonary dysplasia, and elevated perinatal mortality rates. Therefore, early identification, diagnosis, and treatment of CAM are crucial for optimizing therapeutic success in pregnant women and newborns while enhancing the quality of life and disease prognosis for neonates. This review aims to elucidate the correlation between CAM and neonatal diseases as well as provide insights into current prevention strategies and treatment approaches to offer novel clinical perspectives for improved management of CAM?related newborns.
Binghui LI , Qiong MENG . Research progress on chorioamnionitis and related neonatal diseases[J]. The Journal of Practical Medicine, 2024 , 40(23) : 3411 -3418 . DOI: 10.3969/j.issn.1006-5725.2024.23.021
| 1 | ROMERO R, MIRANDA J, CHAIWORAPONGSA T,et al. Prevalenceandclinical significance ofsterile intra-amniotic inflammation in patients with preterm labor and intact membranes[J]. Am J Reprod Immunol, 2014,72(5):458-474. doi:10.1111/aji.12296 |
| 2 | HIGGINS R D, SAADE G, POLIN R A, et al. Chorioamnionitis Workshop Participants. Evaluation and Management of Women and Newborns With a Maternal Diagnosis of Chorioamnionitis:Summary of a Workshop[J]. Obstet Gynecol, 2016,127(3):426-436. doi:10.1097/aog.0000000000001246 |
| 3 | KOVáCS K, KOVáCS ? Z, BAJZáT D,et al. The histologic fetal inflammatory response and neonatal outcomes: Systematic review and meta-analysis[J]. Am J Obstet Gynecol, 2024,230(5):493-511.e3. doi:10.1016/j.ajog.2023.11.1223 |
| 4 | SEVERINO M E L, RICHARDSON L, KAMMALA A K,et al. Autophagy Determines Distinct Cell Fates in Human Amnion and Chorion Cells[J]. Autophagy Rep, 2024,3(1):2306086. doi:10.1080/27694127.2024.2306086 |
| 5 | SEVERINO M E, RICHARDSON L S, KACEROVSKY M,et al. Histologic Evidence of Epithelial-Mesenchymal Transition and Autophagy in Human Fetal Membranes[J]. Am J Pathol, 2024,194(5):684-692. doi:10.1016/j.ajpath.2023.12.011 |
| 6 | GOMEZ-LOPEZ N, GALAZ J, MILLER D, et al. The immunobiology of preterm labor and birth: Intra-amniotic inflammation or breakdown of maternal-fetal homeostasis[J]. Reproduction, 2022,164(2):R11-R45. doi:10.1530/rep-22-0046 |
| 7 | JACKSON C M, WELLS C B, TABANGIN M E, et al. Pro-inflammatory immune responses in leukocytes of premature infants exposed to maternal chorioamnionitis or funisitis[J]. Pediatr Res,2017,81(2):384-390. doi:10.1038/pr.2016.232 |
| 8 | SCHELONKA R L, MAHESHWARIA, CARLO W A, et al. T cell cytokines and the riskof blood stream infection in extremely low birth weight infants[J]. Cytokine, 2011,53(2):249-255. doi:10.1016/j.cyto.2010.11.003 |
| 9 | KAMDAR S, HUTCHINSON R, LAING A, et al. Perinatal inflammation influences butdoes not arrest rapid immune development in preterm babies[J]. Nat Commun, 2020,11(1):1284. doi:10.1038/s41467-020-14923-8 |
| 10 | ZHANG L, FANG X, LI Z, et al. Establishment of a prediction model for histological chorioamnionitis and its association with outcomes of premature infants[J]. Front Pediatr, 2023,11:1194563. doi:10.3389/fped.2023.1194563 |
| 11 | SHI H, SUN L, WANG Z,et al.Non-invasive prediction of histologic chorioamnionitis using maternal serum markers in women with preterm prelabour rupture of membranes[J]. Am J Reprod Immunol, 2022,88(3):e13594. doi:10.1111/aji.13594 |
| 12 | PENG J, CHEN Y, WAN S, et al. Predictorsfor histological chorioamnionitis among women with preterm prelabour rupture of membranes after dexamethasone treatment: A retrospective study[J]. BJOG, 2023,130(9):1072-1079. doi:10.1111/1471-0528.17431 |
| 13 | ZHANG J, FAN C, XU C, et al.Serumcalciumlevel at 32 weeks of gestation could be applied as a predictor of preterm delivery: A retrospective study[J]. Eur J Med Res, 2024,29(1):400. doi:10.1186/s40001-024-01984-4 |
| 14 | WANG Z, XIU X, ZHONG L, et al. Significance of cervical secretion culture in predicting maternal and fetal outcome in pregnant women with premature rupture of membranes: A retrospective cohort study[J]. Front Pharmacol, 2024,15:1328107. doi:10.3389/fphar.2024.1328107 |
| 15 | BUDAL E B, BENTSEN M H L, KESSLER J, et al. Histologic chorioamnionitis in extremely preterm births, microbiological findings and infant outcome[J]. J Matern Fetal Neonatal Med,2023,36(1):2196599. doi:10.1080/14767058.2023.2196599 |
| 16 | FETTWEIS J M, SERRANO M G, BROOKS J P, et al. The vaginal microbiome and preterm birth[J]. Nat Med, 2019,25(6):1012-1021. |
| 17 | EMRANI S EL, JANSEN E J S, GOEMAN J J,et al. Histological Chorioamnionitis and Funisitis as New Risk Factors for Retinopathy of Prematurity: A Meta-analysis[J]. Am J Perinatol, 2024,41(S 01):e3264-e3273. doi:10.1055/a-2215-0662 |
| 18 | BECK C, GALLAGHER K, TAYLOR L A, et al. Chorioamnionitis and Risk for Maternal and Neonatal Sepsis:A Systematic Review and Meta-analysis[J]. Obstet Gynecol, 2021,137(6):1007-1022. doi:10.1097/aog.0000000000004377 |
| 19 | MOON K C, OH J W, PARK C W, et al. The Relationship Among Intra-Amniotic Inflammatory Response, The Progression of Inflammation in Chorionic Plate and Early-Onset Neonatal Sepsis[J]. Front Pediatr, 2021,9:582472. doi:10.3389/fped.2021.582472 |
| 20 | NOMIYAMA M, NAKAGAWA T, YAMASAKI F,et al. Contribution of Fetal Inflammatory Response Syndrome (FIRS) with or without Maternal-Fetal Inflammation in The Placenta to Increased Risk of Respiratory and Other Complications in Preterm Neonates[J]. Biomedicines, 2023,11(2):611. doi:10.3390/biomedicines11020611 |
| 21 | TONG M, SMITH A H, ABRAHAMS V M. Activated Neutrophils Propagate Fetal Membrane Inflammation and Weakening through ERK and Neutrophil Extracellular Trap-Induced TLR-9 Signaling[J]. J Immunol, 2021,206(5):1039-1045. doi:10.4049/jimmunol.2001268 |
| 22 | NOMIYAMA M, NAKAGAWA T, YAMASAKI F, et al. Contribution of Fetal Inflammatory Response Syndrome (FIRS) with or without Maternal-Fetal Inflammation in The Placenta to Increased Risk of Respiratory and Other Complications in Preterm Neonates[J]. Biomedicines, 2023,11(2):611. doi:10.3390/biomedicines11020611 |
| 23 | 付溪娜,杨桦. 妊娠期下生殖道无乳链球菌定植对围产结局的影响[J]. 中国综合临床, 2023,39(1):38-43. |
| 24 | 甘跃华,陈秋玲. 宫内感染早产儿的菌群分布与耐药情况[J].北方药学,2023,20(1):138-140. |
| 25 | 李菲,石文静. 新生儿早发型败血症的风险评估[J]. 中华新生儿科杂志(中英文), 2023,38(8):509-512. |
| 26 | DASKALAKIS G, PSARRIS A, KOUTRAS A, et al. Maternal Infection and PretermBirth:From Molecular Basis to Clinical Implications[J]. Children (Basel),2023,10(5):907. doi:10.3390/children10050907 |
| 27 | BERGER D S, GARG B, PENFIELD C A, et al. Respiratory distress syndrome is associated with increased morbidity and mortality in late preterm births[J]. Am J Obstet Gynecol MFM,2024,6(6):101374. doi:10.1016/j.ajogmf.2024.101374 |
| 28 | 张倩薇,丁冉,孙启斌,等. 组织学绒毛膜羊膜炎暴露对呼吸窘迫综合征早产儿并发支气管肺发育不良的影响[J]. 中国小儿急救医学, 2021,28(5):380-384. |
| 29 | GIAMBELLUCA S, VERLATO G, SIMONATO M, et al. Chorioamnionitis alters lung surfactant lipidome in newborns with respiratory distress syndrome[J]. Pediatr Res,2021,90(5):1039-1043. doi:10.1038/s41390-021-01371-3 |
| 30 | YU H, LI D, ZHAO X, et al. Fetal origin of bronchopulmonary dysplasia: Contribution of intrauterine inflammation[J]. Mol Med,2024,30(1):135. doi:10.1186/s10020-024-00909-5 |
| 31 | 张杰,梅花,新春,等. 组织学绒毛膜羊膜炎对早产儿支气管肺发育不良影响的Meta分析[J]. 中华新生儿科杂志(中英文),2024,39(8):480-485. |
| 32 | ZHANG C, CAO J, XU M, et al. The role of neutrophils in chorioamnionitis[J]. Front Immunol,2023,14:1198831. doi:10.3389/fimmu.2023.1198831 |
| 33 | DANKHARA N, HOLLA I, RAMARAO S, et al. Bronchopulmonary Dysplasia: Pathogenesis and Pathophysiology[J]. J Clin Med,2023,12(13):4207. doi:10.3390/jcm12134207 |
| 34 | TUGRUL ERSAK D, ?ERBET?I H, LALELI KO? B,et al. Placental Pathology and Its Importance in Preterm Infants[J]. Fetal Pediatr Pathol,2023,42(5):746-752. doi:10.1080/15513815.2023.2223297 |
| 35 | 张林夕,段翌,高奥会,等. 组织学绒毛膜羊膜炎与胎龄< 34 周早产儿支气管肺发育不良的相关性分析[J]. 中华新生儿科杂志,2020,35(3):186-190. |
| 36 | COSTA S, FATTORE S, DE SANTIS M, et al. Effect of acute histologic chorioamnionitis on bronchopulmonary dysplasia and mortality rate among extremely low gestational age neonates: A retrospective case-control study[J]. Int J Gynaecol Obstet, 2024,165(3):1040-1046. doi:10.1002/ijgo.15290 |
| 37 | 余紫薇,殷静,钱云,等. 中性粒细胞胞外诱捕网在支气管肺发育不良中的研究进展[J]. 国际儿科学杂志, 2023,50(4):257-261. |
| 38 | MAREGA M, EL-MERHIE N, G?KYILDIRIM M Y, et al. Stem/Progenitor Cells and Related Therapy in Bronchopulmonary Dysplasia[J]. Int J Mol Sci, 2023,24(13):11229. doi:10.3390/ijms241311229 |
| 39 | SUN T, YU H Y, YANG M, et al. Risk of asthma in preterm infants with bronchopulmonary dysplasia: A systematic review and meta-analysis[J]. World J Pediatr, 2023,19(6):549-556. doi:10.1007/s12519-023-00701-1 |
| 40 | NINAN K, LIYANAGE S K, MURPHY K E, et al. Evaluation of Long-term Outcomes Associated With Preterm Exposure to Antenatal Corticosteroids: A Systematic Review and Meta-analysis[J]. JAMA Pediatr, 2022,176(6):e220483. doi:10.1001/jamapediatrics.2022.0483 |
| 41 | GE H, QIAO Y, GE J, et al. Effects of early vitamin D supplementation on the prevention of bronchopulmonary dysplasia in preterm infants[J]. Pediatr Pulmonol, 2022,57(4):1015-1021. doi:10.1002/ppul.25813 |
| 42 | 陈天雨,陈筱青. 特异性促炎症消退介质保护支气管肺发育不良的研究进展[J]. 中华新生儿科杂志(中英文), 2024,39(7):435-438. |
| 43 | ZHANG S, MULDER C, RIDDLE S, et al. Mesenchymal stromal/stem cells and bronchopulmonary dysplasia[J]. Front Cell Dev Biol, 2023,11:1247339. doi:10.3389/fcell.2023.1247339 |
| 44 | SáNCHEZ-ROSADO M, REIS J D, JALEEL M A,et al. Impact of Size for Gestational Age on Multivariate Analysis of Factors Associated with Necrotizing Enterocolitis in Preterm Infants: Retrospective Cohort Study[J]. Am J Perinatol,2024,41(11):1544-1553. doi:10.1055/a-2183-5155 |
| 45 | GARG P M, PASCHAL J L, ANSARI M A Y, et al. Association of Placental Pathologic Findings with the Severity of Necrotizing Enterocolitis in Preterm infants - A Matched Case-Control Study[J]. Fetal Pediatr Pathol,2023,42(2):187-197. doi:10.1080/15513815.2022.2110340 |
| 46 | MIR I N, SáNCHEZ-ROSADO M, REIS J, et al. Impact of fetal inflammatory response on the severity of necrotizing enterocolitis in preterm infants[J]. Pediatr Res,2024,95(5):1308-1315. doi:10.1038/s41390-023-02942-2 |
| 47 | DVORAK B, HALPERN M D, HOLUBEC H,et al. Maternalmilk reducesseverityof necrotizing enterocolitis and increases intestinal IL-10 in a neonatal rat model[J]. Pediatr Res, 2003,53(3):426-433. doi:10.1203/01.pdr.0000050657.56817.e0 |
| 48 | ZHANG X, ZHANG Y, HE Y, et al. β-glucan protects against necrotizing enterocolitis in mice by inhibiting intestinal inflammation, improving the gut barrier, and modulating gut microbiota[J]. J Transl Med, 2023,21(1):14. doi:10.1186/s12967-022-03866-x |
| 49 | PERRONE S, CREMONINI I, MARINELLI F, et al. New Strategies for Necrotizing Enterocolitis Diagnosis and Prevention in Newborns[J]. Curr Pediatr Rev, 2021,17(3):191-200. doi:10.2174/1573396317666210426102610 |
| 50 | WU S, DI S, LIU T, et al. Emerging prediction methods for early diagnosis of necrotizing enterocolitis[J]. Front Med (Lausanne),2022,9:985219. doi:10.3389/fmed.2022.985219 |
| 51 | 方凌毓,陈江滨,刘志勇,等. 肠组织氧饱和度和粪便钙卫蛋白对早产儿坏死性小肠结肠炎诊断效能和病情严重性的评估[J]. 中国小儿急救医学, 2024,31(1):35-40. |
| 52 | 温燕,张坤英,温慧. 新生儿坏死性小肠结肠炎预防与管理的最佳证据总结[J]. 中国小儿急救医学, 2024,31(6):443-448. |
| 53 | AGAKIDOU E, AGAKIDIS C, KONTOU A, et al. Antimicrobial Peptides in Early-Life Host Defense, Perinatal Infections, and Necrotizing Enterocolitis-An Update[J]. J Clin Med,2022,11(17):5074. doi:10.3390/jcm11175074 |
| 54 | WANG H, CHEN D, LI H, et al. Bifidobacterium regulates premature infant gut metabolites, reducing serum inflammatory factors: A randomised controlled trial[J]. Pediatr Res, 2024.doi: 10.1038/s41390-024-03552-2 . |
| 55 | KELLY S B, DEAN J M, ZAHRA V A, et al. Progressive inflammation reduces high-frequency EEG activity and cortical dendritic arborisation in late gestation fetal sheep[J]. J Neuroinflammation,2023,20(1):124. doi:10.1186/s12974-023-02805-x |
| 56 | SPINILLO A, DOMINONI M, MAS F D,et al. Placental fetal vascular malperfusion, neonatal neurologic morbidity, and infant neurodevelopmental outcomes: A systematic review and meta-analysis[J]. Am J Obstet Gynecol, 2023,229(6):632-640.e2. doi:10.1016/j.ajog.2023.06.014 |
| 57 | GALL A R, AMOAH S, KITASE Y, et al. Placental mediated mechanisms ofperinatal brain injury: Evolving inflammation and exosomes[J]. Exp Neurol, 2022,347:113914. doi:10.1016/j.expneurol.2021.113914 |
| 58 | JAIN V G, KLINE J E, HE L, et al. Acute histologic chorioamnionitisindependently and directly increases the risk for brain abnormalities seenon magneticresonance imaging in very preterm infants[J].Am J Obstet Gynecol, 2022,227(4):623.e1-623.e13. doi:10.1016/j.ajog.2022.05.042 |
| 59 | 张馨月. 急性组织绒毛膜羊膜炎直接增加极早产儿MRI脑部异常风险[J]. 中华围产医学杂志, 2023,26(1):52. |
| 60 | GUSSENHOVEN R, WESTERLAKEN R, OPHELDERS D, et al. Chorioamnionitis, neuroinflammation, and injury: Timing is key in the preterm ovine fetus[J]. J Neuroinflammation, 2018,15(1):113. doi:10.1186/s12974-018-1149-x |
| 61 | 冯梦婷,纪琼,朱梦如,等. 胎儿炎症反应综合征导致新生儿脑损伤机制的研究进展[J]. 中华新生儿科杂志(中英文), 2024,39(3):186-189。 |
| 62 | GISSLEN T, SINGH G, GEORGIEFF M K F, et al. inflammation is associated with persistent systemic and hippocampal inflammation and dysregulation of hippocampal glutamatergic homeostasis[J]. Pediatr Res, 2019,85(5):703-710. doi:10.1038/s41390-019-0330-y |
| 63 | 侯新琳. 早产儿脑损伤监测技术进展[J]. 中华新生儿科杂志(中英文), 2024,39(3):132-135. |
| 64 | KELLY S B, STOJANOVSKA V, ZAHRA V A, et al. Interleukin-1 blockade attenuates white matter inflammation and oligodendrocyte loss after progressive systemic lipopolysaccharide exposure in near-term fetal sheep[J]. J Neuroinflammation,2021,18(1):189. doi:10.1186/s12974-021-02238-4 |
| 65 | MEI S H, HAITSMA J J, DOS SANTOS C C, et al. Mesenchymal stem cells reduce inflammation while enhancing bacterial clearance and improving survival in sepsis[J]. Am J Respir Crit Care Med, 2010,182(8):1047-1057. doi:10.1164/rccm.201001-0010oc |
| 66 | KOTHARI N, DSOUZA V, MISHRA U,et al. A symptomatic full-term infants born to women with chorioamnionitis may not need routine antibiotics[J]. Acta Paediatr, 2021,110(11):3000-3005. doi:10.1111/apa.16059 |
| 67 | LIN L L, HUNG J N, SHIU S I. Efficacy of prophylactic antibiotics for preterm premature rupture of membranes: A systematic review and network meta-analysis[J]. Am J Obstet Gynecol MFM, 2023,5(7):100978. doi:10.1016/j.ajogmf.2023.100978 |
| 68 | CONDE-AGUDELO A, ROMERO R, JUNG E J,et al. Management of clinical chorioamnionitis: An evidence-based approach[J]. Am J Obstet Gynecol,2020,223(6):848-869. doi:10.1016/j.ajog.2020.09.044 |
| 69 | VENKATESH K K, HUGHES B L, GROTEGUT C A, et al. Preoperative cefazolin rather than clindamycin ormetronidazole is associated with lower postpartum infection among women with chorioamnionitis delivering by cesarean delivery[J]. Am J Obstet Gynecol MFM, 2020,2(1):100074. doi:10.1016/j.ajogmf.2019.100074 |
| 70 | SHQARA R ABU, GLIKMAN D, JAD S,et al. Antibiotic treatment of women with isolated intrapartum fever vs clinical chorioamnionitis: Maternal and neonatal outcomes[J]. Am J Obstet Gynecol, 2023,229(5):540.e1-540.e9. doi:10.1016/j.ajog.2023.05.013 |
/
| 〈 |
|
〉 |