The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 16: 2250 - 2255

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.16.009

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Study on the relationship between serum LRG1， LDH with periodontal indexes and periodontal lesions in patients with type 2 diabetes and chronic periodontitis

  • Tingting YANG ,
  • Yidan HUANG ,
  • Rongrong YANG ,
  • Ying YANG ,
  • Jing. ZHANG
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  • *.Department of Periodontology，Hospital of Stomatology，General Hospital of Ningxia Medical University，Yinchuan 750004，China

Received date: 2024-03-11

  Online published: 2024-08-26

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Abstract

Objective To explore the relationship between serum leucine 2-rich glycoprotein 1 （LRG1）， lactate dehydrogenase （LDH） with periodontal indicators and periodontal lesions degree in patients with type 2 diabetes mellitus （T2DM） and chronic periodontitis （CP）. Methods 112 patients with T2DM combined with CP admitted to our hospital from July 2022 to July 2023 （T2DM combined with CP group） were selected and categorized into mild， moderate， and severe groups according to the degree of periodontal pathology； 112 patients with CP alone （CP group） were selected from our hospital during the same period， and then 112 patients with T2DM alone （T2DM group） were selected； and LRG1， LDH， and periodontal indexes were measured； Pearson method was applied to analyze the correlation between serum LRG1， LDH， and periodontal indicators. The influencing factors of severe T2DM combined with CP were analyzed using multivariate logistic regression. ROC curve was plotted to analyze the diagnostic value of serum LRG1 and LDH for severe T2DM combined with CP. Results The levels of LRG1 and LDH in the CP group， T2DM group， and T2DM combined with CP group increased sequentially （P < 0.05）. The levels of serum LRG1， LDH， AL， PD， and BI increased sequentially in the mild， moderate， and severe groups （P < 0.05）. According to Pearson correlation analysis， serum LRG1 was positively correlated with LDH （P < 0.05）. Serum LRG1 and LDH were positively correlated with AL， PD， and BI （P < 0.05）. According to logistic regression analysis， LRG1， LDH， AL， PD， and BI were all factors for severe T2DM combined with CP （P < 0.05）. According to the ROC curve， the AUC for the combined diagnosis of serum LRG1 and LDH in severe T2DM with CP was 0.910， and the combination of the two was better than their individual diagnosis （Z combination vs LRG1= 2.659， Z combination vs LDH=2.627， P < 0.05）. Conclusion LRG1 and LDH are greatly elevated in the serum of patients with T2DM combined with CP， and they are related to periodontal indicators and the periodontal lesions degree.

Key words： type 2 diabetes mellitus; chronic periodontitis; leucine rich alpha-2-glycoprotein 1; lactate dehydrogenase; periodontal indicators; periodontal lesions; correlation

Cite this article

Tingting YANG , Yidan HUANG , Rongrong YANG , Ying YANG , Jing. ZHANG . Study on the relationship between serum LRG1， LDH with periodontal indexes and periodontal lesions in patients with type 2 diabetes and chronic periodontitis[J]. The Journal of Practical Medicine, 2024 , 40(16) : 2250 -2255 . DOI: 10.3969/j.issn.1006-5725.2024.16.009

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