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Association between TyG⁃WC and risk of coronary heart disease in middle⁃aged and elderly population： a prospective cohort study with 10⁃year follow⁃up
Received date: 2023-10-18
Online published: 2024-06-14
Objective To investigate the association between triglyceride glucose index（TyG） combined with waist circumference （WC） and the risk of new-onset coronary heart disease （CHD） in the middle-aged and elderly people in 10 years of non-interventional follow-up in Luzhou area. Methods A total of 8 647 eligible individuals participated in epidemiological survey in Luzhou area were selected. The subjects were divided into different groups according to the quartiles of the TyG-WC and followed for ten years. The correlation between different TyG-WC quartile group and 10-year new CHD in middle-aged and elderly population was analyzed by using univariate analysis and Cox regression analysis. Results Of the 8 647 participants in the study， 484 had new CHD， accounting for 5.5%. The comparison of the number of newly diagnosed CHD subjects grouped by TyG-WC quartiles indicated the 4th quartile group > the 3rd quartile group > the 2nd quartile group > the 1st quartile group， showing statistical significance （P < 0.001）. Cox regression analysis showed that without adjusting for any variables， the risk of new CHD in 10 years increased with the increase of TyG-WC quartile group， and the differences between the second， third and fourth quartile array and the first quartile array were statistically significant （P < 0.05）. After adjusting for age and sex and further adjusting for the influence of various influencing factors， the risk of new CHD in 10 years increased with the increase of TyG-WC quartile group. The difference between the third and fourth quartile array and the first quartile array was statistically significant （P < 0.05）. Conclusion TyG-WC is a risk factor for new-onset CHD in the middle-aged and elderly population in Luzhou area in 10 years of non-interventional follow-up， and TyG-WC may be a predictor of the risk of CHD in the middle-aged and elderly population.
Yu WANG , Ying MIAO , Qiang LIN , Mao TIAN , Zhuang CHEN , Qin WAN . Association between TyG⁃WC and risk of coronary heart disease in middle⁃aged and elderly population： a prospective cohort study with 10⁃year follow⁃up[J]. The Journal of Practical Medicine, 2024 , 40(12) : 1731 -1736 . DOI: 10.3969/j.issn.1006-5725.2024.12.020
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