The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 11: 1554 - 1559

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.11.015

Clinical Research

Effects of sevoflurane and propofol on perioperative HIF⁃1α levels and postoperative recovery in patients undergoing bariatric surgery

  • Shan′e DUAN ,
  • Mingzhu ZHONG ,
  • Qingde ZHANG ,
  • Xuemei. PENG
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  • *.Department of Anesthesia，the First Affiliated Hospital of Jinan University，Guanzhou 510630，China

Received date: 2023-11-30

  Online published: 2024-06-13

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Abstract

Objective This study aimed to investigate the differential effects of sevoflurane and propofol on perioperative HIF-1α levels and postoperative recovery in patients undergoing bariatric surgery. Methods A total of 40 obese patients （BMI ≥ 44 kg/m2） were randomly allocated into two groups： sevoflurane （n = 21） group and propofol （n = 19） group. The quantitative measurement of HIF-1α levels in human serum at different time points was conducted using ELISA. The assessment of redness， swelling， pain， exudation， and prognosis-related indicators of the patient's umbilical incision was performed at 24 and 48 hours after surgery. Results On the day following surgery， there was a significant increase in HIF-1α levels in the sevoflurane group and a significant decrease in the propofol group. The frequency and type of opioid analgesics used in the sevoflurane group were significantly lower than those used in the propofol group after surgery. Conclusions Compared with propofol， sevoflurane is more suitable for maintaining anesthesia in obese patients undergoing bariatric surgery. Sevoflurane can promote enhanced recovery after surgery by reducing postoperative analgesic consumption and upregulating HIF-1α levels.

Key words： sevoflurane; propofol; HIF-1α

Cite this article

Shan′e DUAN , Mingzhu ZHONG , Qingde ZHANG , Xuemei. PENG . Effects of sevoflurane and propofol on perioperative HIF⁃1α levels and postoperative recovery in patients undergoing bariatric surgery[J]. The Journal of Practical Medicine, 2024 , 40(11) : 1554 -1559 . DOI: 10.3969/j.issn.1006-5725.2024.11.015

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