The Journal of Practical Medicine >

2024 , Vol. 40 >Issue 3: 321 - 325

DOI: https://doi.org/10.3969/j.issn.1006-5725.2024.03.007

Clinical Research

Clinical significance of HOXB4 gene expression levels in myelodysplastic syndromes

  • Yichen WANG ,
  • Yanwen YAN ,
  • Meihui SONG ,
  • Xiangjun XUE ,
  • Wenguang ZHOU ,
  • Yuquan LI ,
  • Ling QI ,
  • Guanghua LI ,
  • Xiangzong ZENG
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  • College of Basic Medicine，Dali University，Dali 671000，China； *Institute of Digestive Disease，the Sixth Affiliated Hospital of Guangzhou Medical University，Qingyuan People's Hospital，Qingyuan 511518，China

Received date: 2023-08-28

  Online published: 2024-02-22

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Abstract

Objective To investigate the expression of HOXB4 gene in patients with myelodysplastic syndromes （MDS） and its clinical significance in disease progression. Methods mRNA expression of HOXB4 gene in bone marrow mononuclear cells was detected by real?time fluorescence quantitative PCR （RT?qPCR）， and the difference in HOXB4 expression was compared between 49 patients with MDS （MDS group） and 35 patients without MDS （group C）. The relationship of mRNA expression of HOXB4 with disease characteristics and clinical prognosis was explored in MDS patients. Results mRNA expression level of HOXB4 gene was higher in MDS group than that in group C （P < 0.05）. The patients were divided into a high? and a low?expression group according to the median expression level of HOXB4. Leukocyte count was lower in the high?expression group in the low?expression group at the time of initial diagnosis. The proportion of patients with subtypes of primitive cellular hyperplasia， poor prognostic staging and leukemic transformation was higher in the high?expression group than in the low?expression group. Conclusions mRNA expression level of HOXB4 gene has certain relation with AML transformation in MDS patients.

Key words： myelodysplastic syndrome; HOXB4; prognosis; leukemia transformation

Cite this article

Yichen WANG , Yanwen YAN , Meihui SONG , Xiangjun XUE , Wenguang ZHOU , Yuquan LI , Ling QI , Guanghua LI , Xiangzong ZENG . Clinical significance of HOXB4 gene expression levels in myelodysplastic syndromes[J]. The Journal of Practical Medicine, 2024 , 40(3) : 321 -325 . DOI: 10.3969/j.issn.1006-5725.2024.03.007

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