The Journal of Practical Medicine >

2023 , Vol. 39 >Issue 17: 2271 - 2276

DOI: https://doi.org/10.3969/j.issn.1006-5725.2023.17.021

Reviews

Research progress of necroptosis in ophthalmology and clinical application of its inhibitors

  • Xinlin YAN ,
  • Xuan. LI
Expand
  • Tianjin Eye Hospital，Nankai University，Tianjin 300020，China

Received date: 2023-06-19

  Online published: 2023-09-27

Fold

Abstract

Necroptosis is a major discovery in the field of cell death in recent decades. At present， in the field of ophthalmology， the activation of necroptosis pathway has been found from corneal diseases， glaucoma， retinal diseases and so on. In addition to Necrostatin-1（Nec-1）， a necroptosis inhibitor targeting receptor-interacting protein1（RIP1）， drugs such as GSK2399872A（GSK872）， a receptor-interacting protein3（RIP3） inhibitor， and TC13172， a novel inhibitor targeting mixed lineage kinase domain-like protein （MLKL）， have made major breakthroughs in cell death mechanisms. Currently in the field of ophthalmology， necroptosis inhibitors have demonstrated their protective effects in a variety of disease models. This article focuses on the molecular mechanism of necroptosis and the research results of its inhibitors in ophthalmology， discusses the potential of necroptosis as a new target for the treatment of ophthalmic diseases， and puts forward suggestions for its further research in the field of ophthalmology.

Key words： cell death; necroptosis; receptor-interacting protein1/3; mixed lineage kinase domain-like protein; Necrostatin-1; cornea; glaucoma; retina

Cite this article

Xinlin YAN , Xuan. LI . Research progress of necroptosis in ophthalmology and clinical application of its inhibitors[J]. The Journal of Practical Medicine, 2023 , 39(17) : 2271 -2276 . DOI: 10.3969/j.issn.1006-5725.2023.17.021

References

1 LASTER S M， WOOD J G， GOODING L R. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis［J］. J Immunol， 1988， 141（8）： 2629-2934.
2 DAI W， CHENG J， LENG X， et al. The potential role of necroptosis in clinical diseases （Review） ［J］. Int J Mol Med， 2021， 47（5）：89.
3 LIU X， XIE X， REN Y， et al. The role of necroptosis in disease and treatment［J］. Med Comm （2020）， 2021， 2（4）： 730-755.
4 SHAN B， PAN H， NAJAFOV A， et al. Necroptosis in development and diseases ［J］. Genes Dev， 2018， 32（5-6）： 327-340.
5 胡建生，王雯，刘海旺，等. 坏死性凋亡机制及在结直肠肿瘤中的研究进展［J］. 实用医学杂志， 2021， 37（8）： 1088-1092.
6 BERTHELOOT D， LATZ E， FRANKLIN B S. Necroptosis， pyroptosis and apoptosis： an intricate game of cell death［J］. Cell Mol Immunol， 2021， 18（5）： 1106-1121.
7 TANG D， KANG R， BERGHE T V， et al. The molecular machinery of regulated cell death［J］. Cell Res， 2019，29（5）： 347-364.
8 YANG D， LIANG Y， ZHAO S， et al. ZBP1 mediates interferon-induced necroptosis［J］. Cell Mol Immunol， 2020，17（4）： 356-368.
9 CAO L， MU W. Necrostatin-1 and necroptosis inhibition： Pathophysiology and therapeutic implications［J］. Pharmacol Res， 2021， 163：105297.
10 SAEED W K， JUN D W， JANG K， et al. Necroptosis signaling in liver diseases： An update ［J］. Pharmacol Res， 2019，148：104439.
11 LIU M， LI H， YANG R， et al. GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1/RIP3/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma［J］. J Neuroinflammation， 2022，19（1）：262.
12 JI Y， WARD L A， HAWKINS C J. Reconstitution of Human Necrosome Interactions in Saccharomyces cerevisiae［J］. Biomolecules， 2021，11（2）：153.
13 MIFFLIN L， OFENGEIM D， YUAN J. Receptor-interacting protein kinase 1 （RIPK1） as a therapeutic target［J］. Nat Rev Drug Discov， 2020，19（8）：553-571.
14 BROTHERS K M， CALLAGHAN J D， STELLA N A， et al. Blowing epithelial cell bubbles with GumB： ShlA-family pore-forming toxins induce blebbing and rapid cellular death in corneal epithelial cells［J］. PLoS Pathog， 2019，15（6）： e1007825.
15 GUO H， KOEHLER H S， MOCARSKI E S， et al. RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis［J］. PLoS Pathog， 2022，18（9）： e1010857.
16 UETA T， ISHIHARA K， NOTOMI S， et al. RIP1 kinase mediates angiogenesis by modulating macrophages in experimental neovascularization［J］. Proc Natl Acad Sci USA， 2019，116（47）： 23705-23713.
17 YU D， DENG Q， WANG J， et al. Air Pollutants are associated with Dry Eye Disease in Urban Ophthalmic Outpatients： a Prevalence Study in China［J］. J Transl Med， 2019，17（1）： 46.
18 SHI K， YIN Q， TANG X， et al. Necroptosis contributes to airborne particulate matter-induced ocular surface injury［J］. Toxicology， 2022， 470： 153140.
19 YOU X G， FAN T J， JIANG G J. Phenylephrine induces necroptosis and apoptosis in corneal epithelial cells dose- and time-dependently［J］. Toxicology， 2019，428： 152305.
20 JIANG G J， LI B B， FAN T J. Timolol induces necroptosis， apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro［J］. Life Sci， 2021，277： 119453.
21 SHANG L， DING W， LI N， et al. The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure［J］. Acta Biochim Biophys Sin （Shanghai）， 2017，49（2）： 128-137.
22 LIAO L， SHANG L， LI N， et al. Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure［J］. Acta Biochim Biophys Sin （Shanghai）， 2017，49（10）： 879-889.
23 KIM C R， KIM J H， PARK H L， et al. Ischemia Reperfusion Injury Triggers TNFα Induced-Necroptosis in Rat Retina［J］. Curr Eye Res， 2017，42（5）： 771-779.
24 DING W， SHANG L， HUANG J F， et al. Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation［J］. BMC Neurosci， 2015，16： 49.
25 HANUS J， ANDERSON C， SARRAF D， et al. Retinal pigment epithelial cell necroptosis in response to sodium iodate［J］. Cell Death Discov， 2016， 2： 16054.
26 JANG K H， DO Y J， KOO T S， et al. Protective effect of RIPK1-inhibitory compound in in vivo models for retinal degenerative disease［J］. Exp Eye Res， 2019，180： 8-17.
27 DING J， YANG N， YAN Y， et al. Rapamycin Inhibited Photoreceptor Necroptosis and Protected the Retina by Activation of Autophagy in Experimental Retinal Detachment［J］. Curr Eye Res， 2019， 44（7）： 739-745.
28 DONG K， HAN L， LIU J， et al. RNA Interference Reveals the Coregulatory Effects of Cylindromatosis on Apoptosis and Necroptosis of Photoreceptor Cells in Experimental Retinal Detachment［J］. Am J Pathol， 2017，187（8）： 1763-1771.
29 DARUICH A， LE ROUZIC Q， JONET L， et al. Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection［J］. Sci Adv， 2019，5（1）： eaau9940.
Options
Outlines

/

〈 〉