Burn is a post⁃traumatic inflammatory disease. Multiple organ failure is the main cause of death after burn. Excessive systemic and local inflammation directly leads to terminal organ injury. Liver is the largest metabolic and detoxification organ of the human body，and it is easy to be attacked by endotoxin. The deterioration of liver function will lead to increased morbidity and mortality of burn patients. Therefore，the repair of hepatic injury after severe burn is of great significance. Although progress has been made in the clinical management of burns， there are still limitations in the treatment of severe burns. In recent years，Mesenchymal stem cells（MSCs）have shown great promise in tissue repair. In this review，we will focus on the role of MSCs in severe burn⁃induced hepatic injury.