Infection of Helicobacter pylori（H.pylori）has become one of the intractable problems in the field of public health. It was identified asan association with many gastrointestinal diseases. Specially，its associa⁃ tion with gastric cancer that has been confirmed by substantial evidence.At present ，the studies that attend to explore the pathogenic mechanism of Hp mainly focus on the protein of virulence factor. As a newly identified virulence factor，the blood group antigen ⁃binding adhesion（BabA）has obtained a great attention on its roles for Hp to induce the occurrence and development of gastric cancer. This paper will comprehensively review the structure and function of BabA，its expression regulation，gastric cancer⁃promoting roles and clinical application，aiming to provide direction for developing new strategies in preventing and treating gastric cancer.