Acute ischemic stroke is a clinical syndrome manifesting nerve function impairment caused by brain ischemia and hypoxia. Antiplatelet therapy is the basis for the prevention and treatment of acute cerebral infarction. As a novel antiplatelet drug and inhibitor of GP IIb/IIIa receptor，tirofiban has been basically mature in the treatment of cardiovascular diseases. However，application of tirofiban for cerebrovascular diseases is still in the exploratory stage，and the administration routes，dosage and safety are still controversial. This paper reviews the application and research progress of tirofiban in the treatment of acute ischemic stroke.