The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (11): 1409-1413.doi: 10.3969/j.issn.1006⁃5725.2021.11.007

• Basic Research • Previous Articles     Next Articles

R697+.32 Effect and mechanism of amlodipine on prostatic hyperplasia in castrated rats 

LI Zhuo，MO Jierong#，YE Mushi，MO Yanyan，PENG Zhihong，WU Haokai，LIU Jianjun.    

  1. Department of Urological Surgery，Affiliated Hos⁃ pital of Guangdong MedicalUniversity，Zhanjiang 524000，China；#Department of Emergency，the First People's Hospital of Foshan，Foshan 528000，China 

  • Online:2021-06-10 Published:2021-06-10
  • Contact: LIU Jianjun E⁃mail：jianjunliulab@163.com

Abstract:

Objective To explore the influence and mechanism of amlodipine on prostatic hyperplasia. Methods A total of 42 male mice randomly assigned to 6 groups（n = 7 in each group）. The rats were sacrificed， and the prostatic ventral lobes were removed and weighed. The volume of the lobes was measured to calculate the PI. Hematoxylin and eosin staining were used to observe the histopathological changes，and in situ VEGF expression was evaluated by IHC. Western blot was used to detect Bcl⁃2 and Bax expression levels，and RT⁃PCR was used to detect the AR expression level. Results Low⁃dose amlodipine significantly decreased the VEGF expression in the prostate tissues，in addition to decreasing the Bcl⁃2 levels and the Bcl⁃2/Bax ratio. Conclusions Amlodipine inhibited prostatic hyperplasia by downregulating VEGF，AR，Bcl⁃2 and the ratio of Bcl⁃2/Bax to induce apoptosis. 

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