脑小血管病患者血清磷酸化Tau蛋白-181、γ-谷氨酰转肽酶、沉默信息调节因子1与睡眠障碍的相关性

doi:10.3969/j.issn.1006-5725.2025.12.014

Abstract

Abstract:

Objective To explore the correlation between serum phosphorylated Tau protein-181 （P-Tau181）， gamma glutamyl transpeptidase （GGT）， silent information regulator 1（SIRT1） and sleep disorders in patients with cerebral small vessel disease. Methods A total of 156 patients with cerebral small vessel disease （CSVD） were divided into a sleep disorder group （PSQI ≥ 10） and a normal sleep group （PSQI < 10） based on the Pittsburgh Sleep Quality Index （PSQI） scores. Serum levels of P-Tau181， GGT， and SIRT1 were compared between the two groups， and the predictive value of these biomarkers for the development of sleep disorders in CSVD patients was analyzed. Results Among 156 patients with cerebral small vessel disease （CSVD）， 52（33.33%） were diagnosed with sleep disorders， and their Pittsburgh Sleep Quality Index （PSQI） scores were significantly higher than those of the normal sleep group （P < 0.05）. The serum levels of P-Tau181， GGT， and SIRT1 in the sleep disorder group were elevated compared to the normal sleep group （P < 0.05）. Positive correlations were observed between PSQI scores and P-Tau181， GGT， and SIRT1 levels （P < 0.05）. The areas under the curve （AUC） for predicting sleep disorders in CSVD patients using individual biomarkers （P-Tau181， GGT， SIRT1） and their combined prediction were 0.672， 0.742， 0.749， and 0.843， respectively. Conclusion The abnormal expression of P-Tau181， GGT， and SIRT1 is associated with sleep disorders in patients with cerebral small vessel disease.

Key words: cerebral small vessel disease, sleep disorders, P-Tau181, GGT, SIRT1

CLC Number:

R743.32

Li ZHANG,Yunting FU. The correlation between serum P⁃Tau181， GGT， SIRT1 and sleep disorders in patients with cerebral small vessel disease[J]. The Journal of Practical Medicine, 2025, 41(12): 1867-1872.

Figures/Tables 7

Tab.1

Comparison of baseline data between two groups"

因素	睡眠障碍组（n = 52）	睡眠正常组（n = 104）	$χ 2$ /t值	P值
年龄（x ± s）/岁	62.53 ± 4.71	61.09 ± 5.27	1.665	0.098
性别			0.120	0.729
男	32（61.54）	61（58.65）
女	20（38.46）	43（41.35）
合并症
糖尿病	16（30.77）	27（25.96）	0.401	0.526
高血压	22（42.31）	29（27.88）	3.277	0.070
慢性支气管炎	14（26.92）	17（16.35）	2.436	0.119
脑小血管病类型			1.082	0.781
腔隙性脑梗死	21（40.38）	50（48.08）
脑微出血	8（15.38）	14（13.46）
脑微梗死	22（42.31）	37（35.58）
脑萎缩	1（1.92）	3（2.88）
GDS评分（x ± s）/分	3.19 ± 0.72	3.04 ± 0.65	1.310	0.192

Tab.1

Tab.2

Tab.3

Tab.4

Tab.5

Tab.6

Fig.1

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组别	例数	P-Tau181/（ng/L）	GGT/（U/L）	SIRT1/（ng/μL）
睡眠障碍组	52	70.62 ± 13.04	76.03 ± 16.47	1.86 ± 0.31
睡眠正常组	104	55.09 ± 10.51	60.04 ± 15.83	1.29 ± 0.26
t值		8.014	2.868	12.091
P值		0.001	0.001	0.001

组别	例数	TC/（mmol/L）	TG/（mmol/L）	LDL-C/（mmol/L）	FBG/（mmol/L）	Hcy/（μmol/L）	Aβ1-42/（pg/mL）
睡眠障碍组	52	4.85 ± 0.82	1.46 ± 0.32	2.76 ± 0.41	4.72 ± 1.36	12.03 ± 1.67	39.64 ± 4.15
睡眠正常组	104	4.63 ± 0.79	1.41 ± 0.39	2.70 ± 0.45	4.51 ± 1.09	11.95 ± 1.25	38.41 ± 3.92
t值		1.619	0.799	0.808	1.042	0.336	1.820
P值		0.107	0.425	0.420	0.299	0.738	0.071

指标		P-Tau181	GGT	SIRT1
PSQI	r值	0.402	0.364	0.561
PSQI	P值	0.001	0.002	0.001

因素	b	S_b	Wald χ²	P值	OR	95%CI
因素	b	S_b	Wald χ²	P值	OR	下限	上限
P-Tau181	1.465	0.652	5.049	0.001	4.328	1.728	10.839
GGT	1.491	0.684	4.752	0.001	4.442	1.773	11.125
SIRT1	1.702	0.679	5.283	0.001	5.485	2.189	13.738

指标	Cut-off	灵敏度	特异度	AUC	95%CI
指标	Cut-off	灵敏度	特异度	AUC	下限	上限
P-Tau181	62.51 ng/L	0.65	0.68	0.672	0.584	0.813
GGT	68.43 U/L	0.75	0.71	0.742	0.642	0.839
SIRT1	1.57 ng/μL	0.77	0.74	0.749	0.641	0.853
三项联合	-	0.89	0.63	0.843	0.761	0.925

The correlation between serum P⁃Tau181， GGT， SIRT1 and sleep disorders in patients with cerebral small vessel disease

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