昼夜节律基因调控消化系统肿瘤及中药干预作用的研究进展

doi:10.3969/j.issn.1006-5725.2025.05.005

Abstract

Abstract:

Circadian rhythms， a result of the long-term evolution of organisms adapting to the Earth's environment， play a crucial regulatory role in biological activities. Disruptions in circadian rhythms have been identified as potential carcinogenic risk factors， closely linked to the pathological states of digestive system diseases， and significantly contribute to the occurrence and progression of digestive system tumors. These rhythms not only influence the regulation of cell cycles， proliferation， and apoptosis of tumor cells but also profoundly affect their migratory abilities， immune functions， and drug resistance. This article focuses on the specific regulatory mechanisms of circadian rhythm genes in relation to digestive system tumors and comprehensively summarizes research findings on the anti-tumor effects of traditional Chinese medicine targeting these circadian clock genes. The aim is to provide new avenues for target selection and prognostic evaluation in the treatment of digestive system tumors.

Key words: circadian rhythm, circadian clock genes, digestive system tumors, traditional Chinese medicine, mechanism

CLC Number:

R735

Shuo SUN,Wenjie ZHANG,Yi ZHAO,Youzhi. SUN. Research progress on circadian rhythm genes regulating digestive system tumors and the intervention of traditional Chinese medicine[J]. The Journal of Practical Medicine, 2025, 41(5): 648-656.

Figures/Tables 3

References 97

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生物钟基因	肝癌	胃癌	结直肠癌	胰腺癌
CLOCK	低表达^［41］	高表达^［77］	高表达^［50］	低表达^［37］
BMAL1	低表达^［41］	高表达^［47］	高表达^［58］	低表达^［49］
TIMELESS	高表达^［52］	低表达^［36］	高表达^［57］	低表达^［94］
NPAS2	高表达^［39］	高表达^［83］	低表达^［35］	/
PER1/2/3	低表达^［66］	高表达^［77］	低表达^［80］	低表达^［79］
CRY1/2	低表达^［45］	高表达^［45］	高表达^［59］	低表达^［84］
REVERB-α	/	低表达^［51］	/	/

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Research progress on circadian rhythm genes regulating digestive system tumors and the intervention of traditional Chinese medicine

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