阿司匹林对子宫内膜异位症合并薄型子宫内膜冻融胚胎移植的影响

doi:10.3969/j.issn.1006-5725.2025.01.016

Abstract

Abstract:

Objective To analyze the effect of aspirin addition on endometrial conditions and pregnancy outcomes in endometriosis-related patients with thin endometrium. Methods A retrospective analysis was conducted on endometriosis-related patients with thin endometrium （thickness < 7 mm） undergoing frozen-thawed embryo transfer at the Reproductive Medical Centre from January 2019 to May 2023 was conducted. Patients undergoing hormone replacement therapy with aspirin （Observation group， n = 162） were compared with those receiving increased estrogen alone （Control group， n = 152）. Endometrial parameters before embryo transfer and clinical outcomes were compared between the groups. Results Compared to the Control group， the Observation group showed significant improvements in pulsatility index （PI）［（0.77 ± 0.20） vs. （0.84 ± 0.27），P < 0.05］， resistance index （RI）［（0.49 ± 0.10） vs. （0.63 ± 0.10），P < 0.01］， and systolic/diastolic （S/D） ratio ［（1.94 ± 0.49） vs. （2.22 ± 0.47），P < 0.01］. Moreover， there was a significant increase in the embryo implantation rate （38.00% vs. 27.24%， P < 0.01）， clinical pregnancy rate （56.17% vs. 42.11%， P < 0.05） and live birth rate （84.62% vs. 68.75%， P < 0.05）. Conclusion In endometriosis-related patients with thin endometrium， the addition of aspirin significantly improved uterine and spiral artery blood flow， thereby enhancing pregnancy outcomes during frozen-thawed embryo transfer.

Key words: endometriosis, thin endometrium, aspirin, frozen embryo transfer

CLC Number:

R711.6

Min ZHOU,Xiaoxiao ZHANG,Zhao WU. The effect of aspirin on frozen thawed embryo transfer in endometriosis with thin endometrium[J]. The Journal of Practical Medicine, 2025, 41(1): 95-99.

Figures/Tables 3

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References 25

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组别	年龄/岁	不孕年限/年	BMI/（kg/m²）	AMH/（ng/mL）	基础FSH/（mIU/mL）	移植胚胎数/个
观察组	30.04 ± 3.11	3.44 ± 2.31	21.77 ± 3.04	4.86 ± 3.26	6.06 ± 2.82	1.85 ± 0.36
对照组	29.48 ± 3.42	3.09 ± 1.82	21.53 ± 2.32	4.61 ± 3.38	6.48 ± 2.16	1.84 ± 0.37
t/χ²值	1.53	1.50	0.80	0.66	-1.50	0.40
P值	0.13	0.14	0.42	0.51	0.14	0.70

组别	内膜厚度/mm	PI	RI	S/D
观察组	7.40 ± 1.32	0.77 ± 0.20	0.49 ± 0.10	1.94 ± 0.49
对照组	7.35 ± 1.06	0.84 ± 0.27	0.63 ± 0.10	2.22 ± 0.47
t值	0.35	-2.34	-12.08	-5.17
P值	0.73	0.02	< 0.01	< 0.01
组别	内膜容积/mm³	VI/%	FI	VFI
观察组	3.18 ± 1.02	5.28 ± 3.60	25.54 ± 4.53	1.58 ± 1.17
对照组	3.13 ± 0.87	5.00 ± 3.27	25.91 ± 4.56	1.57 ± 1.15
t值	0.49	0.71	-0.73	0.12
P值	0.63	0.48	0.47	0.91

组别	胚胎着床率	临床妊娠率	活产率	双胎妊娠率	早期流产率
观察组	38.00（114/300）	56.17（91/162）	84.62（77/91）	24.18（22/91）	13.19（12/91）
对照组	27.24（76/279）	42.11（64/152）	68.75（44/64）	18.75（12/64）	25.00（16/64）
χ²值	7.59	6.21	5.52	0.65	3.54
P值	< 0.01	0.01	0.02	0.42	0.06

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The effect of aspirin on frozen thawed embryo transfer in endometriosis with thin endometrium

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