The Journal of Practical Medicine ›› 2021, Vol. 37 ›› Issue (19): 2464-2467.doi: 10.3969/j.issn.1006⁃5725.2021.19.006

• Clinical Research • Previous Articles     Next Articles

Early miscarriage rate before and after IVF/ICSI in infertile patients with endometriosis：A retrospective study

ZHOU Min，GUO Chun.   

  1. Center for Reproductive Medicine，Department of Obstetrics and Gynecology，Univer⁃ sity of Electronic Science and Technology of China，Sichuan Provincial People′s Hospital，Chengdu 610072，China

  • Online:2021-10-10 Published:2021-10-10
  • Contact: GUO Chun E⁃mail：chunguo11@hotmail.com

Abstract:

Objective To study the early miscarriage rate of in vitro fertilization in infertile patients with endometriosis（EMs）. Methods Pregnancy outcomes of 198 infertile patients with EMs and 179 infertility patients with tubal problems treated with IVF or ICSI in our hospital from January 2016 to March 2021 were retro⁃ spectively investigated. Results The early miscarriage rate of natural pregnancy in the endometriosis group was significantly higher than that in the control group（25.60% vs. 14.55%，P < 0.05）. After IVF or ICSI，the fertiliza⁃ tion rate and high⁃quality embryo rate in the endometriosis group were significantly lower than those in the control group，respectively（69.22% vs. 79.53%；51.91% vs. 59.19%，P < 0.05）. The early miscarriage rate after the im⁃ plantation of fresh or frozen embryos in the EMS patients was significantly higher than that in the control group， respectively（24.39% vs. 7.14%，21.31% vs. 4.69%，P < 0.05）. Conclusion The fertilization rate and high⁃quality embryo rate are lower and the early miscarriage rate is higher in the EMS patients，indicating that endometriosis may lead to infertility by impairing the embryo quality and other factors. 

Key words:

endometriosis, in vitro fertilization, miscarriage