髌下脂肪垫高信号强度对膝骨关节炎症状及结构的相关性

doi:10.3969/j.issn.1006-5725.2024.23.015

Abstract

Abstract:

Objective To analyze the correlation between high signal intensity of infrapatellar fat pad （IPFP） and symptoms and structural changes of osteoarthritis of the knee in patients with osteoarthritis of the knee based on image digitization. Methods Imaging and clinical data of patients with knee osteoarthritis （KOA） were retrospectively analyzed. The differences in knee osteoarthritis symptoms and structural changes in patients with different IPFP high signal intensities were compared， and the relationship between IPFP high signal intensity changes and knee osteoarthritis symptoms as well as structural changes was also analyzed. Results A total of 219 patients （268 knees） were collected and completed imaging measurements and evaluations， and the median IPFP high signal intensity （27.40%） was used to compare the groups. The IPFP high signal intensity ≥ 27.40% group had a significantly higher degree of tibial cartilage damage， changes in knee angle， pain， and total scores on the osteoarthritis index （western ontario and mcMaster）. universities osteoarthritis index （WOMAC） were significantly higher than those in the IPFP high signal intensity < 27.40% group， with a statistically significant difference （P < 0.05）； IPFPF high signal intensity changes were associated with knee pain， joint line convergence angle， JLCA， and knee joint angle. Angle （JLCA）， knee kellgren?Lawrence （KL） classification， and the degree of femoral and tibial cartilage damage were significantly positively correlated （P < 0.05）. Conclusion In patients with KOA， there is a significant correlation between IPFP high signal intensity changes and knee pain symptoms as well as structural changes， which may be an important factor influencing the progression of KOA.

Key words: knee osteoarthritis, infrapatellar fat pad, magnetic resonance imaging, high signal intensity

CLC Number:

R684.3

Yuke SONG,Jinfan XU,Xiaoming HE,Tianye LIN,Mincong HE,Qiushi. WEI. Correlation of high signal intensity of infrapatellar fat pad on symptoms and structure of knee osteoarthritis[J]. The Journal of Practical Medicine, 2024, 40(23): 3373-3378.

Figures/Tables 6

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References 23

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指标	小于中位数组（n = 147）	大于中位数组（n = 147）	t/χ²/Z值	P值
年龄（x ± s）/岁	64.87 ± 7.62	66.47 ± 7.63	-1.824	0.068
性别/例（%）
男	22（14.97）	29（19.73）	1.162	0.281
女	125（85.03）	118（80.27）
患侧/例（%）
左	78（53.06）	67（45.58）	1.647	0.199
右	69（46.94）	80（54.42）
IPFP/mm²
IPFP面积	575.58 ± 85.81	568.19 ± 100.19	-1.187	0.235
IPFP高信号面积	118.9 ± 30.19	203.01 ± 53.08	-13.145	0.000
下肢力线角度/°
HKA	176.33 ± 4.27	175.2 ± 5.04	-2.100	0.036
JLCA	2.69 ± 1.84	3.37 ± 2.27	-2.148	0.032
K-L分级/例
Ⅱ	8	8	6.959	0.031
Ⅲ	114	95
Ⅳ	25	44
软骨损伤/例
髌骨
Ⅰ	21	11	4.263	0.234
Ⅱ	26	29
Ⅲ	48	45
Ⅳ	52	62
股骨
Ⅰ	22	13	6.963	0.073
Ⅱ	40	30
Ⅲ	56	60
Ⅳ	29	44
胫骨
Ⅰ	0	0	7.928	0.019
Ⅱ	3	2
Ⅲ	45	25
Ⅳ	99	120
WOMAC评分/分
疼痛	11.51 ± 2.07	11.98 ± 1.91	-1.975	0.048
僵硬	3.67 ± 1.14	3.75 ± 1.25	-0.919	0.358
功能障碍	35.28 ± 8.65	36.25 ± 8.89	-0.951	0.342
总分	50.46 ± 8.99	51.98 ± 9.21	-1.429	0.154

因变量	单因素分析		多因素分析
因变量	β（95% CI）	P值	β（95% CI）	P值
WOMAC评分
疼痛	4.514（9.763 ~ 11.181）	0.000^△	4.537（2.143 ~ 6.930）	0.000
僵硬	0.931（-0.519 ~ 2.381）	0.208	0.944（-0.512 ~ 2.401）	0.203
功能障碍	-3.425（-14.140 ~ 7.236）	0.525	-4.505（-15.156 ~ 6.147）	0.406
总分	1.993（-9.128 ~ 13.113）	0.725	0.977（-10.120 ~ 12.073）	0.863

因变量	单因素分析		多因素分析
因变量	β（95% CI）	P值	β（95% CI）	P值
HKA	-4.624（-10.261 ~ 1.014）	0.108	-4.711（-10.354 ~ 0.931）	0.101
JLCA	3.490（0.967 ~ 6.012）	0.0077	3.643（1.134 ~ 6.151）	0.005
K-L分级	3.392（0.740 ~ 6.043）	0.012	3.487（0.824 ~ 6.151）	0.010
软骨损伤
髌骨	1.135（-1.086 ~ 3.357）	0.317	1.316（-0.942 ~ 3.524）	0.257
股骨	3.283（1.037 ~ 5.528）	0.004	3.235（0.982 ~ 5.488）	0.005
胫骨	5.592（2.436 ~ 8.747）	0.001	5.442（2.266 ~ 8.618）	0.001

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Correlation of high signal intensity of infrapatellar fat pad on symptoms and structure of knee osteoarthritis

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