The Journal of Practical Medicine ›› 2024, Vol. 40 ›› Issue (7): 898-903.doi: 10.3969/j.issn.1006-5725.2024.07.004

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Relationship between endometrial lactobacillus⁃dominated microbiota and reproduction

Biyun ZHANG1,2,Xingming ZHONG1,2,Xiaoxia WANG1,Xiaohua. LIU2,3   

  1. Department of Reproductive Immunology,Guangdong Provincial Reproductive Hospital (Guangdong Institute of Reproductive Sciences),Guangzhou 510600,China,Guangzhou 510600,China
    Key Laboratory of Male Reproduction and Genetics,National Health Commission,Guangzhou 510600,China
  • Received:2023-10-16 Online:2024-04-10 Published:2024-04-08

Abstract:

An increasing number of studies in recent years have focused on the association between female endometrial microbiota and fertility. Once the endometrial microflora microecology is unbalanced, it will cause a series of endometrial lesions, thereby destroying endometrial receptivity, affecting embryo implantation, resulting in embryo implantation or implantation failure. Among them, the most concerned is the positive significance of lactobacillus-led microbiota on reproductive outcome. Although the relationship between endometrial microbiota and reproductive outcome has not reached a consensus, most studies recognize the positive impact of lactobacillus-led microbiota on reproductive outcome. In this review, the relationship between lactobacillus-dominated microbiota and reproductive outcome is reviewed.

Key words: lactobacillus-dominated microbiota, non-lactobacillus-dominated microbiota, endometrial microbiota, recurrent spontaneous abortion, pregnancy

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