The Journal of Practical Medicine ›› 2024, Vol. 40 ›› Issue (1): 119-122.doi: 10.3969/j.issn.1006-5725.2024.01.021

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Application of metagenomics next⁃generation sequencing in the diagnosis and treatment of spinal infection

Siping LONG1,2,Zhili LIU1,3,Shanhu HUANG1,3,Jiaming. LIU1,3()   

  1. *.Department of Orthopedics,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China
    *.The Fourth School of Clinical Medicine of Nanchang University,Nanchang 330100,China
  • Received:2023-09-25 Online:2024-01-10 Published:2024-01-24
  • Contact: Jiaming. LIU E-mail:liujiamingdr@hotmail.com

Abstract:

The incidence of spinal infections, a relatively rare infectious disease, is on the rise due to the empirical use of antibiotics that increases the chances of infection with drug?resistant bacteria, as well as advances in testing technology that have led to an increase in detection rates. Identifying the type of pathogen to target antibiotics is the key to treatment. However, conventionaldetection methods have low detection rates and are time?consuming, which are not conducive to the rapid and accurate diagnosis of spinal infection. Metagenomics next?generation sequencing (mNGS) is a detection technique that can sequence all nucleic acid fragments in samples,the emergence of which subverts traditional detection methods and plays an important role in the diagnosis and treatment of spinal infections. This article summarizes the application of mNGS in the diagnosis and treatment of spinal infection.

Key words: metagenomics next?generation sequencing, spinal infection, pathogens, clinical medication

CLC Number: