Abstract:

Objective To investigate the association of matrix metalloproteinase⁃9（MMP⁃9） with matrix metalloproteinase inhibitor（TIMP ⁃1）expression in serum of patients with chronic obstructive pulmonary disease （COPD），and its predictive value for pulmonary vascular remodeling（PVR）. Methods A total of 1，091 patients with COPD who were hospitalized from January 2019 to December 2021 were selected as research objects. Accord⁃ ing to clinical diagnosis，the patients were divided into acute exacerbation group and stable stage group. Serum expression levels of MMP⁃9 and TIMP⁃1 in COPD patients were compared，and correlation analysis was conducted on statistical results. Moreover，the specificity of serum MMP⁃9 and TIMP⁃1 expression in The specificity of pulmo⁃ nary vascular remodeling prediction was compared. Results The relative expression levels of MMP⁃9 and TIMP⁃1 in patients with acute exacerbation were significantly higher than those in stable COPD group（P < 0.01）. By Pearson correlation analysis，the expression of MMP⁃9 and TIMP⁃1 in serum of COPD patients showed a significant positive correlation.Serum levels of MMP⁃9 and TIMP⁃1 in patients with pulmonary vascular remodeling were higher in the acute exacerbation stage than in the stable stage group.Analysis of the efficacy of MMP⁃9 and TIMP⁃1 in predicting pulmonary vascular remodeling showed that the specificity of COPD patients at acute exacerbation stage was compared with that at stable stage（P < 0.01），and the difference was statistically significant. Conclusion The expression of MMP⁃9 and TIMP⁃1 in serum of patients with chronic obstructive pulmonary disease can be used asserological biomarkers for COPD assessment and prediction of pulmonary vascular remodeling （PVR），which has important clinical significance.

Key words:

chronic obstructive pulmonary disease, matrix metalloproteinase ? 9, matrix metallopro? teinase inhibitor?1, pulmonary vascular remodeling, pulmonary arterial hypertension