Abstract:

Vascular aging， characterized by increased arterial stiffness， vascular wall remodeling， and endothelial dysfunction， is a crucial factor in the occurrence and development of cardiovascular diseases， such as hypertension， atherosclerosis， and cardiac insufficiency. Palmitoylation， a post-translational modification of proteins that involves the addition of palmitic acid， plays a pivotal role in vascular aging. Protein palmitoylation exerts a regulatory effect on the process of vascular aging by modulating the membrane localization， stability， and signal transduction of key proteins in vascular cells， and by participating in oxidative stress， inflammation amplification， impaired endothelial barrier function， abnormal transformation of smooth muscle phenotype， autophagy， and protein homeostasis imbalance. These effects are interwoven and influence the occurrence and development of various cardiovascular-related disease events. Protein palmitoylation is of great significance in vascular aging and offers an important strategy for the prevention and treatment of related cardiovascular events.

Key words: cardiovascular disease, vascular aging, related cardiovascular diseases, palmitoylation modification, DHHC palmitoyltransferase, protein post-translational modification