The Journal of Practical Medicine ›› 2025, Vol. 41 ›› Issue (8): 1205-1211.doi: 10.3969/j.issn.1006-5725.2025.08.017
• Clinical Research • Previous Articles
Rui GUO1,Tao LIU1,Xi. SU2
Received:
2025-01-08
Online:
2025-04-25
Published:
2025-04-30
CLC Number:
Rui GUO,Tao LIU,Xi. SU. Establishment of a nomogram model for comorbid cardiovascular disease in schizophrenia based on electrocardiogram parameters and kynurenine metabolites[J]. The Journal of Practical Medicine, 2025, 41(8): 1205-1211.
Tab.1
Clinical data, electrocardiographic parameters, KYN metabolites in the two groups"
项目 | PSM前 | t/χ2 /Z值 | P值 | PSM后 | t/χ2 /Z值 | P值 | ||
---|---|---|---|---|---|---|---|---|
共患组 (n = 100) | 非共患组 (n = 486) | 共患组 (n = 100) | 非共患组 (n = 100) | |||||
男/女/例 | 51/49 | 257/229 | 0.118 | 0.732 | 51/49 | 55/45 | 2.000 | 0.157 |
年龄/岁 | 55.45 ± 4.36 | 46.38 ± 5.12 | 16.522 | < 0.001 | 55.45 ± 4.36 | 47.22 ± 4.89 | 12.562 | < 0.001 |
BMI/(kg/m2) | 26.84 ± 1.32 | 23.22 ± 1.08 | 29.322 | < 0.001 | 26.84 ± 1.32 | 24.42 ± 1.36 | 12.769 | < 0.001 |
首次发病年龄/岁 | 26.68 ± 3.47 | 27.11 ± 2.68 | 1.384 | 0.167 | 26.68 ± 3.47 | 27.20 ± 2.59 | 1.201 | 0.231 |
PANSS量表/分 | 103.21 ± 11.13 | 102.78 ± 12.57 | 0.317 | 0.751 | 103.21 ± 11.13 | 102.36 ± 13.44 | 0.487 | 0.627 |
阳性症状 | 25.24 ± 3.36 | 24.71 ± 3.48 | 1.395 | 0.164 | 25.24 ± 3.36 | 24.78 ± 3.44 | 0.957 | 0.340 |
阴性症状 | 23.38 ± 4.42 | 22.96 ± 4.59 | 0.838 | 0.402 | 23.38 ± 4.42 | 23.11 ± 4.48 | 0.429 | 0.668 |
一般精神症状 | 54.59 ± 5.27 | 55.11 ± 5.32 | 0.892 | 0.373 | 54.59 ± 5.27 | 54.47 ± 5.20 | 0.162 | 0.871 |
婚姻状况/[例(%)] | 0.081 | 0.776 | 0.340 | 0.560 | ||||
已婚 | 60(60.00) | 299(61.52) | 60(60.00) | 64(64.00) | ||||
未婚 | 40(40.00) | 187(38.48) | 40(40.00) | 36(36.00) | ||||
文化程度/[例(%)] | 0.553 | 0.580 | 0.203 | 0.840 | ||||
初中及以下 | 29(29.00) | 131(26.96) | 29(29.00) | 26(26.00) | ||||
高中 | 50(50.00) | 240(49.38) | 50(50.00) | 54(54.00) | ||||
大专及以上 | 21(21.00) | 115(23.66) | 21(21.00) | 20(20.00) | ||||
糖尿病/[例(%)] | 31.727 | < 0.001 | 0.216 | 0.642 | ||||
有 | 31(31.00) | 48(9.88) | 31(31.00) | 28(28.00) | ||||
无 | 69(69.00) | 438(90.12) | 69(69.00) | 72(72.00) | ||||
高脂血症/[例(%)] | 27.625 | < 0.001 | 10.526 | < 0.001 | ||||
有 | 28(28.00) | 44(9.05) | 28(28.00) | 10(10.00) | ||||
无 | 72(72.00) | 442(90.95) | 72(72.00) | 90(90.00) | ||||
精神疾病家族史/[例(%)] | 1.910 | 0.167 | 1.087 | 0.297 | ||||
有 | 10(10.00) | 30(6.17) | 10(10.00) | 6(6.00) | ||||
无 | 90(90.00) | 456(93.83) | 90(90.00) | 94(94.00) | ||||
吸烟/[例(%)] | 25.750 | < 0.001 | 7.812 | < 0.001 | ||||
有 | 33(33.00) | 61(12.55) | 33(33.00) | 16(16.00) | ||||
无 | 67(67.00) | 425(87.45) | 67(67.00) | 64(64.00) | ||||
饮酒/[例(%)] | 14.547 | < 0.001 | 5.357 | 0.021 | ||||
有 | 22(22.00) | 43(8.85) | 22(22.00) | 10(10.00) | ||||
无 | 78(78.00) | 443(91.15) | 78(78.00) | 90(90.00) | ||||
睡眠障碍/[例(%)] | 30.531 | < 0.001 | 0.184 | 0.668 | ||||
有 | 44(44.00) | 90(18.52) | 44(44.00) | 41(41.00) | ||||
无 | 56(56.00) | 396(81.48) | 56(56.00) | 59(59.00) | ||||
心电图参数 | ||||||||
QTc/ms | 473.44 ± 122.26 | 348.48 ± 103.71 | 10.627 | < 0.001 | 473.44 ± 122.26 | 350.52 ± 104.44 | 7.644 | < 0.001 |
TP-Tec/ms | 122.19 ± 36.51 | 86.51 ± 23.32 | 12.483 | < 0.001 | 122.19 ± 36.51 | 87.41 ± 25.21 | 7.839 | < 0.001 |
KYN代谢物 | ||||||||
TRP/(ng/mL) | 11 988.12 ± 3590.41 | 8 394.43 ± 2 516.69 | 11.994 | < 0.001 | 11 988.12 ± 3 590.41 | 8 390.11 ± 252.38 | 9.997 | < 0.001 |
KYN/(ng/mL) | 20.57 ± 5.48 | 15.05 ± 4.41 | 10.907 | < 0.001 | 20.57 ± 5.48 | 15.12 ± 4.28 | 7.838 | < 0.001 |
KYNA/(nmol/L) | 3.44 ± 0.98 | 2.41 ± 0.65 | 13.088 | < 0.001 | 3.44 ± 0.98 | 2.42 ± 0.61 | 8.836 | < 0.001 |
Tab.3
Logistic regression equations for co-morbid cardiovascular disease in schizophrenia"
自变量 | 赋值 | β | S.E. | Wald χ2 | OR | 95%CI | P值 |
---|---|---|---|---|---|---|---|
常数项 | -0.453 | 0.115 | 15.239 | < 0.001 | |||
BMI | 原值 | 0.414 | 0.105 | 15.541 | 1.513 | 1.134 ~ 2.018 | < 0.001 |
吸烟 | 有=1,无=0 | 0.895 | 0.213 | 17.646 | 2.447 | 1.452 ~ 4.123 | < 0.001 |
饮酒 | 有=1,无=0 | 1.227 | 0.342 | 12.878 | 3.412 | 2.011 ~ 5.789 | < 0.001 |
睡眠障碍 | 有=1,无=0 | 0.856 | 0.258 | 11.013 | 2.354 | 1.305 ~ 4.247 | < 0.001 |
QTc | 原值 | 0.481 | 0.143 | 11.309 | 1.618 | 1.121 ~ 2.334 | < 0.001 |
TP-Tec | 原值 | 0.544 | 0.137 | 15.774 | 1.723 | 1.233 ~ 2.408 | < 0.001 |
TRP | 原值 | 0.418 | 0.126 | 10.983 | 1.518 | 1.152 ~ 2.001 | < 0.001 |
KYN | 原值 | 0.400 | 0.091 | 15.541 | 1.492 | 1.200 ~ 1.856 | < 0.001 |
KYNA | 原值 | 0.583 | 0.165 | 10.616 | 1.712 | 1.246 ~ 2.352 | < 0.001 |
1 | 刘娜,王天道,余春柳,等. 精神分裂症患者血清催乳素和胶质纤维酸性蛋白与预后的关系[J]. 实用医学杂志,2023,39(16):2090-2094. |
2 |
GEBREEGZIABHERE Y, HABATMU K, MIHRETU A,et al.Cognitive impairment in people with schizophrenia: An umbrella review[J]. Eur Arch Psychiatry Clin Neurosci,2022,272(7):1139-1155. doi:10.1007/s00406-022-01416-6
doi: 10.1007/s00406-022-01416-6 |
3 |
HAGI K, NOSAKA T, DICKINSON D,et al. Association Between Cardiovascular Risk Factors and Cognitive Impairment in People With Schizophrenia:A Systematic Review and Meta-analysis[J].JAMA Psychiatry,2021,78(5):510-518. doi:10.1001/jamapsychiatry.2021.0015
doi: 10.1001/jamapsychiatry.2021.0015 |
4 |
SALMINEN A. Activation of aryl hydrocarbon receptor (AhR) in Alzheimer's disease: Role of tryptophan metabolites generated by gut host-microbiota[J]. J Mol Med (Berl),2023,101(3):201-222. doi:10.1007/s00109-023-02289-5
doi: 10.1007/s00109-023-02289-5 |
5 |
STIEGER A, HUBER M, YU Z R,et al. Association of Indoleamine 2,3-Dioxygenase (IDO) Activity with Outcome after Cardiac Surgery in Adult Patients[J]. Metabolites,2024,14(6):334. doi:10.3390/metabo14060334
doi: 10.3390/metabo14060334 |
6 |
ZAHID M U, KIRANYAZ S, GABBOUJ M. Global ECG Classification by Self-Operational Neural Networks With Feature Injection[J]. IEEE Trans Biomed Eng,2023,70(1):205-215. doi:10.1109/tbme.2022.3187874
doi: 10.1109/tbme.2022.3187874 |
7 |
HASAN A, FALKAI P, WOBROCK T,et al. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia-a short version for primary care[J]. Int J Psychiatry Clin Pract,2017,21(2):82-90. doi:10.1080/13651501.2017.1291839
doi: 10.1080/13651501.2017.1291839 |
8 |
VOLPE M, GALLO G, MODENA M G,et al. Updated Recommendations on Cardiovascular Prevention in 2022:An Executive Document of the Italian Society of Cardiovascular Prevention[J].High Blood Press Cardiovasc Prev,2022,29(2):91-102. doi:10.1007/s40292-021-00503-4
doi: 10.1007/s40292-021-00503-4 |
9 |
KANG Z W, QIN Y, SUN Y T,et al. Multigenetic Pharmacogeno-mics-Guided Treatment vs Treatment As Usual Among Hospitalized Men With Schizophrenia:A Randomized Clinical Trial[J]. JAMA Netw Open,2023,6(10):e2335518. doi:10.1001/jamanetworkopen.2023.35518
doi: 10.1001/jamanetworkopen.2023.35518 |
10 |
AL-TWEIGERI T, DENT S, SAYED A AL,et al. Using the Appropriate Formula for QT Measurement Can Save Lives[J]. Hematol Oncol Stem Cell Ther,2022,15(1):79-82. doi:10.1016/j.hemonc.2021.06.001
doi: 10.1016/j.hemonc.2021.06.001 |
11 |
VALENZUELA P L, SANTOS-LOZANO A, SACO-LEDO G,et al.Obesity, cardiovascular risk, and lifestyle: Cross-sectional and prospective analyses in a nationwide Spanish cohort[J]. Eur J Prev Cardiol,2023,30(14):1493-1501. doi:10.1093/eurjpc/zwad204
doi: 10.1093/eurjpc/zwad204 |
12 | 刘丹, 苗加伟, 谭子豪, 等. 柚皮苷对心血管疾病的药理作用研究进展[J]. 中国临床药理学与治疗学, 2025, 30(2): 272-281. |
13 |
SCHOOLING C M, ZHAO J V.Insights into Causal Cardiovascular Risk Factors from Mendelian Randomization[J]. Curr Cardiol Rep, 2023,25(2):67-76. doi:10.1007/s11886-022-01829-8
doi: 10.1007/s11886-022-01829-8 |
14 |
HUYNH P, HOFFMANN J D, GERHARDT T,et al. Myocardial infarction augments sleep to limit cardiac inflammation and damage[J]. Nature, 2024,635(8037):168-177. doi:10.1038/s41586-024-08100-w
doi: 10.1038/s41586-024-08100-w |
15 |
ZHU W, HUANG X M, MEI L L,et al.The predictive value of Tp-Te interval,Tp-Te/QT ratio,and QRS-T angle of idiopathic ventricular tachycardia in patients with ventricular premature beats[J]. Clin Cardiol, 2023,46(4):425-430. doi:10.1002/clc.23998
doi: 10.1002/clc.23998 |
16 |
MORIÑA-VÁZQUEZ P, MORALEDA-SALAS M T, LÓPEZ-MASJUAN-RÍOS Á,et al. Improvement in electrocardiographic parameters of repolarization related to sudden death in patients with ventricular dysfunction and left bundle branch block after cardiac resynchronization through His bundle pacing[J]. J Interv Card Electrophysiol, 2023,66(9):2003-2010. doi:10.1007/s10840-023-01526-8
doi: 10.1007/s10840-023-01526-8 |
17 | 李东霞,梁直厚. 长期住院精神分裂症患者心电图QTc间期延长的影响因素分析[J]. 临床精神医学杂志, 2023,33(4):257-261. |
18 | 姚丽红,王亚亚,张媛. AMI并发室性心律失常患者QTc,Tp-Tec间期变化及其与心功能的相关性[J]. 分子诊断与治疗杂志,2023,15(12):2075-2078. |
19 | 苏杭,刘思丽,吴婕. 急性心肌梗死并发室性心律失常及心室重构患者12导联同步心电图监测及预后分析[J]. 海南医学,2023,34(2):180-184. |
20 |
PIRZADA A, CAI J, CORDERO C,et al. Risk Factors for Cardiovascular Disease:Knowledge Gained from the Hispanic Community Health Study/Study of Latinos[J]. Curr Atheroscler Rep,2023,25(11):785-793. doi:10.1007/s11883-023-01152-9
doi: 10.1007/s11883-023-01152-9 |
21 |
RØDEVAND L, RAHMAN Z, HINDLEY G F L,et al. Characterizing the Shared Genetic Underpinnings of Schizophrenia and Cardiovascular Disease Risk Factors[J]. Am J Psychiatry, 2023,180(11):815-826. doi:10.1176/appi.ajp.20220660
doi: 10.1176/appi.ajp.20220660 |
22 |
HAJSL M, HLAVACKOVA A, BROULIKOVA K,et al. Tryptophan Metabolism,Inflammation,and Oxidative Stress in Patients with Neurovascular Disease[J]. Metabolites, 2020,10(5):208. doi:10.3390/metabo10050208
doi: 10.3390/metabo10050208 |
23 |
JAVANI G, BABRI S, FARAJDOKHT F,et al. Mitotherapy restores hippocampal mitochondrial function and cognitive impairment in aged male rats subjected to chronic mild stress[J]. Biogerontology, 2023,24(2):257-273. doi:10.1007/s10522-022-10014-x
doi: 10.1007/s10522-022-10014-x |
24 |
NORI P, HAGHSHENAS R, AFTABI Y,et al. Comparison of moderate-intensity continuous training and high-intensity interval training effects on the Ido1-KYN-Ahr axis in the heart tissue of rats with occlusion of the left anterior descending artery[J]. Sci Rep, 2023,13(1):3721. doi:10.1038/s41598-023-30847-x
doi: 10.1038/s41598-023-30847-x |
25 | 刘洋洋,张帅奇,刘佩,等. 基于机器学习模型探索节点综合拓扑属性在精神分裂症研究中的应用价值[J]. 中华神经医学杂志, 2024,23(7):705-710. |
26 |
NIU X Q, CAO J Q. Predicting lymph node metastasis in colorectal cancer patients: Development and validation of a column chart model[J]. Updates Surg, 2024,76(4):1301-1310. doi:10.1007/s13304-024-01884-6
doi: 10.1007/s13304-024-01884-6 |
27 |
HJORT N L, STOLTENBERG E A. The partly parametric and partly nonparametric additive risk model[J]. Lifetime Data Anal,2023,29(2):372-402. doi:10.1007/s10985-021-09535-3
doi: 10.1007/s10985-021-09535-3 |
[1] | Xingyu CHEN,Ying XIAO,Hualiang LIN,Lawrence Lam.. Study on the association between gaseous pollutants and cardiovascular disease hospitalization, hospitalization costs, and hospitalization days in seven cities of Guangdong province [J]. The Journal of Practical Medicine, 2025, 41(2): 278-287. |
[2] | Xing CHEN,Yan DENG. The role of glutamine metabolic reprogramming in macrophages in cardiovascular disease [J]. The Journal of Practical Medicine, 2024, 40(22): 3262-3267. |
[3] | Tianyue YU,Qian GUO,Hao HU,Yujing SU,Jianhua CHEN. Advances in oxidative stress⁃related pathways with diagnostic and predictive value in schizophrenia [J]. The Journal of Practical Medicine, 2024, 40(20): 2935-2940. |
[4] | Li′na MA,Zhenhua CAO,Bing. YANG. Correlation between sdLDL⁃C, CXCL12 and CVD in diabetic patients [J]. The Journal of Practical Medicine, 2023, 39(22): 2953-2957. |
[5] | Xiaoxia WANG,Qiao HUANG,Min PENG,Tiemei. SHEN. Application of evidence⁃based standardized hospital discharge preparation service in elderly patients [J]. The Journal of Practical Medicine, 2023, 39(22): 3005-3009. |
[6] | Zhengyuan HUANG,Lirong ZHAO,Kexuan ZHANG,Gaohua WANG,Benhong. ZHOU. The neuroregulatory effects and potential applications of urolithins in mental disorders [J]. The Journal of Practical Medicine, 2023, 39(18): 2405-2410. |
[7] | Zhixian JI,Gang LUO,Sibao WANG,Kuiliang WANG,Silin. PAN. Role of left ventricular morphology combined with ST segment depression in prediction of postoperative cardiac dysfunction in infants with patent ductus arteriosus [J]. The Journal of Practical Medicine, 2023, 39(16): 2057-2061. |
[8] | Na LIU,Tiandao WANG,Chunliu YU,Yi. CHEN. Relationships of prognosis of schizophrenic patients with their serum prolactin and glial fibrillary acid protein [J]. The Journal of Practical Medicine, 2023, 39(16): 2090-2094. |
[9] | ZHANG Xiaoming, GUO Bin, LIU Yanru, ZHANG Fangfang, LIU Huaqing, WANG Zhiren. . Correlation between serum FGF2,TRPC1 levels and psychiatric symptoms in patients with schizophrenia [J]. The Journal of Practical Medicine, 2023, 39(11): 1422-1426. |
[10] |
CHEN Le, QIU Yiling, JIANG Yanping. .
Experience of implementing extracorporeal membrane oxygenation in the management of pregnant females complicated with critical cardiovascular diseases [J]. The Journal of Practical Medicine, 2022, 38(24): 3135-3140. |
[11] |
LI Liu, YU Jianhua. .
Research progress on risk factors and prevention and treatment of AIDS ⁃related cardiovascular diseases [J]. The Journal of Practical Medicine, 2021, 37(20): 2687-2691. |
[12] |
LU Cailian, HUANG Zhengyuan, CHEN Hon⁃ gxu, LI Shan, KANG Lin, XIONG Peng..
Research progress of long non⁃coding RNA in schizophrenia [J]. The Journal of Practical Medicine, 2021, 37(19): 2559-2562. |
[13] |
LI Jia, LIN Yin, JI Xunqi, KANG Yanhai, DONG Jie..
Association of APOE and MTHFR C677T gene polymorphisms with schizophrenia and cognitive function in patients [J]. The Journal of Practical Medicine, 2021, 37(18): 2391-2394. |
[14] |
LI Jia, LIN Yin, JI Xunqi, KANG Yanhai, DONG Jie..
Association of APOE and MTHFR C677T gene polymorphisms with schizophrenia and cognitive function in patients [J]. The Journal of Practical Medicine, 2021, 37(18): 2391-2394. |
[15] |
ZENG Gang, XIAO Aixiang, OUYANG Yanfang, LIANG Rongyu, WU Fengchun, LI Lili, LI Liyan. .
Establishment and effect evaluation of In⁃ward comprehensive rehabilitation model on stable schizophrenia inpatients under closed management [J]. The Journal of Practical Medicine, 2021, 37(12): 1626-1630. |
Viewed | ||||||
Full text |
|
|||||
Abstract |
|
|||||