Abstract:

Objective To analyze the expression levels of TIPE2 and Ki67 in endometrial carcinoma （EC） and their relationship with clinicopathological parameters and prognosis. Methods Tissue samples and clinical data of 96 patients with EC who underwent surgical resection， 120 patients who underwent total hysterectomy due to uterine fibroids and 120 patients who underwent total hysterectomy or curettage admitted to our hospital from February 2020 to February 2022 were retrospectively collected as the research objects， which were divided into the EC group， the normal endometrial group and the atypical hyperplasia endometrial group， respectively. All 3 groups were followed up until March 28， 2023. Immunohistochemistry was used to detect the expression levels of TIPE2 and Ki67 in tissue samples of the three groups， and to analyze the relationship between the levels of TIPE2 and Ki67 and clinicopathological parameters and prognosis. Receiver operating characteristic curve （ROC） was used to analyze its diagnostic value for poor prognosis. Results The expression levels of TIPE2 and Ki67 in cancer tissues of the EC group were higher than those of the normal endometrial group and the atypical hyperplasia endometrial group， and those of the atypical hyperplasia endometrial group were higher than those of the normal endometrial group （P < 0.05）. The expression levels of TIPE2 and Ki67 in EC tissues were higher in patients with FIGO stage Ⅲ， lymph node metastasis， postmenopausal status， and ER and PR negative than patients with stage Ⅱ， no lymph node metastasis， premenopausal status， and ER and PR positive （P < 0.05）. Moreover， the expression level of Ki67 in EC tissues was higher in p53 positive patients than in p53 negative patients （P < 0.05）， and there was a positive correlation between the both expression levels of TIPE2 and Ki67 in EC tissues （r = 0.569， P < 0.05）. Compared with the poor prognosis group， the expression levels of TIPE2 and Ki67 in EC tissues in the good prognosis group were downregulated （P < 0.05）， and the AUC value of the combined detection of TIPE2 and Ki67 expression levels was 0.905， which was significantly higher than that of the single detection （P < 0.05）， sensitivity was 86.67% and specificity was 87.88%， and the predictive value was higher. Conclusion TIPE2 and Ki67 were highly expressed in EC tissues， and there was a positive correlation between the two， and their high expressions were related to clinicopathological features， and their combined detection had high predictive value for poor prognosis of EC.

Key words: endometrial carcinoma, tumor necrosis factor α-induced protein 8 family member 2, cell proliferating nuclear antigen, clinicopathology, prognosis, diagnosis