脑膜淋巴管促进帕金森病α-突触核蛋白外排的研究进展

doi:10.3969/j.issn.1006-5725.2025.16.024

Abstract

Abstract:

Parkinson's disease （PD） is a neurodegenerative disorder whose core pathological feature is the abnormal accumulation of pathological α-synuclein （α-syn） in the brain， but there are rare clinical therapeutic modalities that target this. As a hot research topic in recent years， meningeal lymphatic vessels （MLVs） play an important role in central nervous system fluid （CNS） drainage， and can promote the exocytosis and clearance of metabolic wastes such as α-syn from the brain. Regulating the morphology and function of MLVs to promote α-syn exocytosis is likely to become an influential direction for future intervention in PD research and provide new approaches for the clinical therapy of PD. In this article， we will overview 3 aspects of the structure and function of MLVs， the role of MLVs in PD， and the strategy of targeting MLVs to treat PD.

Key words: Parkinson's disease, meningeal lymphatic vessels, α-synuclein

CLC Number:

R741.02

Die XIAO,Jun MA,Ling QI,Zhaoxie YU,Ya'nan. LI. Meningeal lymphatic vessles promote α-syn efflux in Parkinson's disease[J]. The Journal of Practical Medicine, 2025, 41(16): 2604-2610.

Figures/Tables 1

References 57

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Meningeal lymphatic vessles promote α-syn efflux in Parkinson's disease

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