肠道屏障在肠易激综合征发病机制中的研究进展

doi:10.3969/j.issn.1006-5725.2025.16.023

Abstract

Abstract:

Irritable bowel syndrome （IBS） is a prevalent functional gastrointestinal disorder characterized by a complex etiology involving multiple interacting factors. Accumulating evidence in recent years has indicated that intestinal barrier dysfunction may play a crucial role in the pathogenesis of IBS. This review systematically examines the impact of intestinal barrier dysfunction on IBS， analyzing its associations with the mechanical， immune， chemical， and microbial components of the gut barrier， as well as current clinical treatment approaches. Moreover， this paper highlights the potential of intestinal barrier repair mechanisms as therapeutic targets， which may provide novel insights and directions for understanding the underlying pathophysiological mechanisms and developing effective interventions for IBS.

Key words: irritable bowel syndrome, intestinal barrier, mechanical barrier, chemical barrier, microbial barrier, immune barrier, research advances

CLC Number:

R574.4

Yue HE,Kexin CHENG,Yanqiu LI,Yujun HOU,Siyuan. ZHOU. Research progress on intestinal barrier in irritable bowel syndrome pathogenesis[J]. The Journal of Practical Medicine, 2025, 41(16): 2597-2603.

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Research progress on intestinal barrier in irritable bowel syndrome pathogenesis

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