叉头框蛋白O3a在神经退行性疾病中靶向研究进展

doi:10.3969/j.issn.1006-5725.2024.03.025

Abstract

Abstract:

Neurodegenerative diseases are irreversible neurological disorders caused by the loss or progression lesion of specific neuronal cell populations in the brain or spinal cord. Neuroinflammation， oxidative stress， mitochondrial dysfunction， excitotoxicity， and protein may aggregation contribute to neurodegenerative processes. FoxO3a， an important member of the FoxO subfamily of Forkhead transcription factors， plays a crucial role in cell proliferation， apoptosis， autophagy and ROS detoxification through phosphorylation， ubiquitination mediated degradation， microsignal transduction and related protein pathways， which is closely related to the occurrence and development of neurodegenerative diseases. This article focuses on the mechanism of FoxO3a in neurodegenerative diseases and the targeting of related pathways in recent years were described， indicating that FoxO3a plays a key role in the occurrence and development of the disease， aiming to provide new research ideas for the prevention and treatment of this disease.

Key words: FoxO3a, neurodegenerative diseases, targeted research, review

CLC Number:

R741.02

Sha LI,Chun′ai CUI. Progress in targeted research of forkhead box protein O3a in degenerative disease[J]. The Journal of Practical Medicine, 2024, 40(3): 423-427.

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Progress in targeted research of forkhead box protein O3a in degenerative disease

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