Abstract:

Objective To investigate the clinical value of serum total type I procollagen amino terminal peptide （PINP） and type I collagen carboxyl terminal peptide （β?CTX） combined detection for early prediction of delayed healing of long bone fractures. Methods Serum PINP and β?CTX levels were measured in 156 patients with long bone fracture at 1， 4， 8， 12 weeks after operation. The patients were divided into a delayed healing group （30 cases） and a normal healing group （126 cases） according to the healing status of the fracture. Logistic regression was used to analyze the influencing factors of delayed union of limbs long bone fractures， and ROC curve was used to analyze the early prediction efficiency of postoperative serum PINP and β?CTX combined detection on delayed union of limbs long bone fractures. Results The serum PINP and β?CTX levels in both groups showed an increasing trend after fracture surgery， reaching a peak at 8 weeks after treatment， and then decreasing. The levels of serum PINP and β?CTX in the delayed healing group were lower than those in the normal healing group at 4， 8 and 12 hours after fracture operation， and the difference was statistically significant （P < 0.05）. Multivariate Logistic regression analysis showed that postoperative serum PINP and β?CTX levels were independent risk factors for delayed healing of limb long bone fractures （P < 0.05）. ROC curve showed that the AUC of postoperative serum PINP and β?CTX combined detection in predicting delayed union of long bone fractures was 0.861 （P < 0.05）. Conclusion Postoperative serum PINP and β?CTX levels are closely related to delayed union of limb long bone fractures， and the combined detection of PINP and β?CTX is helpful to early prediction of delayed union of limb long bone fractures.

Key words: Long bone fracture, Delayed healing, Bone transformation marker