儿童睡眠中癫痫性电持续状态脑电图特点与疗效的相关性

doi:10.3969/j.issn.1006-5725.2024.04.015

Abstract

Abstract:

Objective To explore EEG characteristics and the therapeutic effect in children with electrical status epilepticus during slow sleep （ESES）. Methods The eligible ESES cases in our center from 2014 to 2020 were included. The age at diagnosis of ESES， the duration of ESES， spike wave index （SWI） during wakefulness and the distribution of spike wave during the period of ESES， age at seizure onset， the clinical syndromes and the outcomes after treatment were analyzed. The ESES cases were divided into 4 groups according to the distribution of spike wave： focal ESES， unilateral ESES， bilateral asymmetric ESES， multiple foci ESES. The SWI during the awake stage were divided into 3 groups based on the different rates： ≤ 20%， 21% ~ 49%， ≥ 50%. The therapeutic outcomes were classified into three groups： satisfactory response，seizure control and ineffective. Results 50 cases were included， with 32 males and 18 females. The average onset age of ESES was 6 years and 7 months， and the average duration of ESES was 28 months. A significant correlation between the distribution of ESES and the therapeutic effects was found， bilateral asymmetric ESES had a good therapeutic effects， while multiple foci ESES showed a poor therapeutic effects. The duration of ESES was significantly correlated with therapeutic effects，and the efficacy was worse when the duration was longer than 1 year. A significant relationship between the SWI during wakefulness of ESES and the therapeutic effects was detected，the patient with SWI ≤ 20% during wakefulness had a good therapeutic effect.There was a negative correlation between the onset age of ESES and the duration of ESES and SWI index during wakefulness. There was a positive correlation between the duration of ESES and SWI index during wakefulness. Conclusion Our results suggest that onset age，distribution， duration and SWI during wakefulness of ESES were correlated with therapeutic outcomes， The patient with SWI ≤ 20% during wakefulness had a good therapeutic effect and have unfavorable outcomes with ESES last more than 1 year.The earlier onset of ESES， the longer duration of ESES and higher SWI during wakefulness will be showed..

Key words: electrical status epilepticus during slow sleep （ESES）, onset age of ESES, distribution of ESES, duration of ESES, SWI during wakefulness, therapeutic outcomes

CLC Number:

R742.1

Xiuying WANG,Bingwei PENG,Haixia ZHU,Xiaojing LI,Shuyao NING,Wenxiong CHEN,Fangmei. FENG. The correlation between EEG features and therapeutic effect in children with electrical status epilepticus during sleep[J]. The Journal of Practical Medicine, 2024, 40(4): 526-531.

Figures/Tables 6

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References 25

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	一侧性ESES	双侧不对称ESES	多灶性ESES	局灶性ESES	合计	χ²值	P值
合计	12	18	14	6	50	22.35	0.001
ASeLECTs	7（21.2）	17（51.5）	8（24.2）	1（3.0）	33	13.499^a	0.002^a
NIFE	2（15.4）	1（7.7）	5（38.5）	5（38.5）	13	6.008^b	0.08^b
LKS	3（75.0）	0（0.0）	1（25.0）	0（0.0）	4	4.816^c	0.212^c

项目	良好组	控制组	无效组	合计	χ²值	P值
合计	24	13	13	50	15.619	0.016
①一侧性ESES	8	2	2	12	0.455^a 4.105^b 7.218^c	1.0^a 0.127^b 0.023^c
②双侧不对称ESES	13	2	3	18	5.8^d	0.049^d
③局灶性ESES	1	2	3	6	0.781^e	0.818^e
④多灶性ESES	2	7	5	14	11.026^f	0.003^f

项目	良好组	控制组	无效组	合计	χ²/F值	P值
合计	24	13	13	50	11.129	0.025
① ≤ 20%	17	6	2	25	8.148^a	0.017^a
②21% ~ 49%	4	5	6	15	0.637^b	0.876^b
③≥ 50%	3	2	5	10	7.262^c	0.016^c

项目	良好组	控制组	无效组	合计	χ²值	P值
合计	24	13	13	50	8.47	0.017
≤ 12个月	12	2	1	16
≥ 12个月	12	11	12	34

	清醒期SWI指数	ESES持续时间（m）
出现ESES的年龄（y）	-0.304（0.032）	-0.435（0.002）
清醒期SWI指数	/	0.363（0.01）

The correlation between EEG features and therapeutic effect in children with electrical status epilepticus during sleep

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