Abstract:

Objective To explore and analyze the colonization and drug resistance of carbapenem⁃resistant enterobacter（CRE）in patients in internal medicine ICUand to provide guidance for infection control management in ICU. Methods Active anal swab screening for CRE was performed in 394 newly admitted patients in internal medicine ICUfrom March 2017 to December 2018. The isolation and identification of pathogenic bacteria and anti⁃ microbial sensitivity testwere performed in 760 samples. Results Eighty ⁃four positive specimens were detected from 760 samples with a positive rate of 11.05%（84/760）. Furthermore，101 strains of CRE were detected with a total detection rate of 15.63%（101/646）. The detection rate of carbapenem⁃resistant Klebsiellapneumoniae was the highest，accounting for 43.18%（76/176）；followed by Citrobacterfreundii，21.43%（3/14），Enterobacter cloacae， 20.00%（2/10）；Enterobacter aerogenes，16.67%（1/6），Escherichia coli，4.79%（18/376），Proteus mirabilis 2.33%（1/43）. Antimicrobial sensitivity test showed that the drug resistance rate of different carbapenems was varied as follows：etapenem（99.01%），imipenem（81.19%）and meropenem（80.20%）. Conclusion There is high positive value of CRE in active screening，and high drug resistance rate of ertapenem，imipenem and meropenemin ICU of department of internal medicine. Therefore，cluster management of CRE is needed to prevent the outbreak of CRE and provide reference for preventing infection of CRE in hospital.

Key words:

carbapenem?resistant enterobacter（CRE）, colonization, drug?fast, intensive care unit